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Three Genetic-Envir...
Three Genetic-Environmental Networks for Human Personality
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Zwir, Igor (författare)
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Del-Val, Coral (författare)
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Arnedo, Javier (författare)
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visa fler...
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Pulkki-Råback, Laura (författare)
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Konte, Betina (författare)
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Yang, Sarah S. (författare)
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Romero-Zaliz, Rocio (författare)
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Hintsanen, Mirka (författare)
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Cloninger, Kevin M. (författare)
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- Garcia, Danilo, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Psykologiska institutionen,Department of Psychology
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Svrakic, Dragan M. (författare)
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Lester, Nigel (författare)
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Rozsa, Sandor (författare)
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Mesa, Alberto (författare)
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Lyytikäinen, Leo-Pekka (författare)
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Giegling, Ina (författare)
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Kähönen, Mika (författare)
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Martinez, Maribel (författare)
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Seppälä, Ilkka (författare)
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Raitoharju, Emma (författare)
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de Erausquin, Gabriel (författare)
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Mamah, Daniel (författare)
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Raitakari, Olli (författare)
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Rujescu, Dan (författare)
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Postolache, Teodor T. (författare)
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Gu, C. Charles (författare)
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Sung, Joohon (författare)
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Lehtimäki, Terho (författare)
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Keltikangas-Järvinen, Liisa (författare)
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Cloninger, C. Robert (författare)
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visa färre...
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(creator_code:org_t)
- 2019-11-21
- 2021
- Engelska.
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26, s. 3858-3875
- Relaterad länk:
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https://www.nature.c...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Phylogenetic, developmental, and brain-imaging studies suggest that human personality is the integrated expression of three major systems of learning and memory that regulate (1) associative conditioning, (2) intentionality, and (3) self-awareness. We have uncovered largely disjoint sets of genes regulating these dissociable learning processes in different clusters of people with (1) unregulated temperament profiles (i.e., associatively conditioned habits and emotional reactivity), (2) organized character profiles (i.e., intentional self-control of emotional conflicts and goals), and (3) creative character profiles (i.e., self-aware appraisal of values and theories), respectively. However, little is known about how these temperament and character components of personality are jointly organized and develop in an integrated manner. In three large independent genome-wide association studies from Finland, Germany, and Korea, we used a data-driven machine learning method to uncover joint phenotypic networks of temperament and character and also the genetic networks with which they are associated. We found three clusters of similar numbers of people with distinct combinations of temperament and character profiles. Their associated genetic and environmental networks were largely disjoint, and differentially related to distinct forms of learning and memory. Of the 972 genes that mapped to the three phenotypic networks, 72% were unique to a single network. The findings in the Finnish discovery sample were blindly and independently replicated in samples of Germans and Koreans. We conclude that temperament and character are integrated within three disjoint networks that regulate healthy longevity and dissociable systems of learning and memory by nearly disjoint sets of genetic and environmental influences.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Personality
- Memory Systems
- Machine Learning
- Deep Unsupervised Learning
- Genome-wide Association
- Gene-Environment Interaction
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Zwir, Igor
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Del-Val, Coral
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Arnedo, Javier
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Pulkki-Råback, L ...
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Konte, Betina
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Yang, Sarah S.
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visa fler...
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Romero-Zaliz, Ro ...
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Hintsanen, Mirka
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Cloninger, Kevin ...
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Garcia, Danilo, ...
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Svrakic, Dragan ...
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Lester, Nigel
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Rozsa, Sandor
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Mesa, Alberto
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Lyytikäinen, Leo ...
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Giegling, Ina
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Kähönen, Mika
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Martinez, Maribe ...
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Seppälä, Ilkka
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Raitoharju, Emma
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de Erausquin, Ga ...
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Mamah, Daniel
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Raitakari, Olli
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Rujescu, Dan
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Postolache, Teod ...
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Gu, C. Charles
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Sung, Joohon
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Lehtimäki, Terho
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Keltikangas-Järv ...
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Cloninger, C. Ro ...
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visa färre...
- Om ämnet
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
- Artiklar i publikationen
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Molecular Psychi ...
- Av lärosätet
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Göteborgs universitet