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Characterization of...
Characterization of Atrial and Ventricular Structural Remodeling in a Porcine Model of Atrial Fibrillation Induced by Atrial Tachypacing.
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Citerni, Carlotta (författare)
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Kirchhoff, Jeppe (författare)
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Höier Olsen, Lisbeth (författare)
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Sattler, Stefan Michael (författare)
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Gentilini, Fabio (författare)
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Forni, Monica (författare)
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Zannoni, Augusta (författare)
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Grunnet, Morten (författare)
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- Edvardsson, Nils, 1942 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Hjorth Bentzen, Bo (författare)
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Diness, Jonas Goldin (författare)
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(creator_code:org_t)
- 2020-04-09
- 2020
- Engelska.
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Ingår i: Frontiers in veterinary science. - : Frontiers Media SA. - 2297-1769. ; 7:April
- Relaterad länk:
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https://www.frontier...
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https://gup.ub.gu.se...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Atrial fibrillation (AF) is characterized by electrical and structural remodeling. Irregular and/or fast atrio-ventricular (AV) conduction during AF can result in AV dyssynchrony, tachymyopathy, pressure and volume overload with subsequent dilatation, valve regurgitation, and ventricular dysfunction with progression to heart failure. Objective: To gain further insight into the myocardial pathophysiological changes induced by right atrial tachypacing (A-TP) in a large animal model. Methods: A total of 28 Landrace pigs were randomized as 14 into AF-induced A-TP group and 14 pigs to control group. AF pigs were tachypaced for 43 ± 4 days until in sustained AF. Functional remodeling was investigated by echocardiography (after cardioversion to sinus rhythm). Structural remodeling was quantified by histological preparations with picrosirius red and immunohistochemical stainings. Results: A-TP resulted in decreased left ventricular ejection fraction (LVEF) accompanied by increased end-diastolic and end-systolic left atrium (LA) volume and area. In addition, A-TP was associated with mitral valve (MV) regurgitation, diastolic dysfunction and increased atrial and ventricular fibrotic extracellular matrix (ECM). Conclusions: A-TP induced AF with concomitant LV systolic and diastolic dysfunction, increased LA volume and area, and atrial and ventricular fibrosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Citerni, Carlott ...
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Kirchhoff, Jeppe
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Höier Olsen, Lis ...
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Sattler, Stefan ...
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Gentilini, Fabio
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Forni, Monica
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visa fler...
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Zannoni, Augusta
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Grunnet, Morten
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Edvardsson, Nils ...
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Hjorth Bentzen, ...
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Diness, Jonas Go ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Frontiers in vet ...
- Av lärosätet
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Göteborgs universitet