onr:"swepub:oai:gup.ub.gu.se/294163"
Sökning: onr:"swepub:oai:gup.ub.gu.se/294163" > Liver transcriptomi...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04103naa a2200529 4500 | |
| 001 | oai:gup.ub.gu.se/294163 | |
| 003 | SwePub | |
| 008 | 240910s2020 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2941632 URI |
| 024 | 7 | a https://doi.org/10.1136/gutjnl-2019-3192262 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Baselli, G. A.4 aut |
| 245 | 1 0 | a Liver transcriptomics highlights interleukin-32 as novel NAFLD-related cytokine and candidate biomarker |
| 264 | c 2020-01-30 | |
| 264 | 1 | b BMJ,c 2020 |
| 520 | a Objective: Efforts to manage non-alcoholic fatty liver disease (NAFLD) are limited by the incomplete understanding of the pathogenic mechanisms and the absence of accurate non-invasive biomarkers. The aim of this study was to identify novel NAFLD therapeutic targets andbiomarkers by conducting liver transcriptomic analysis in patients stratified by the presence of the PNPLA3 I148M genetic risk variant. Design: We sequenced the hepatic transcriptome of 125 obese individuals. 'Severe NAFLD' was defined as the presence of steatohepatitis, NAFLD activity score ≥4 or fibrosis stage ≥2. The circulating levels of the most upregulated transcript, interleukin-32 (IL32), were measured by ELISA. Results: Carriage of the PNPLA3 I148M variant correlated with the two major components of hepatic transcriptome variability and broadly influenced gene expression. In patients with severe NAFLD, there was an upregulation of inflammatory and lipid metabolism pathways. IL32 was the most robustly upregulated gene in the severe NAFLD group (adjusted p=1×10-6), and its expression correlated with steatosis severity, both in I148M variant carriers and non-carriers. In 77 severely obese, and in a replication cohort of 160 individuals evaluated at the hepatology service, circulating IL32 levels were associated with both NAFLD and severe NAFLD independently of aminotransferases (p<0.01 for both). A linear combination of IL32-ALT-AST showed a better performance than ALT-AST alone in NAFLD diagnosis (area under the curve=0.92 vs 0.81, p=5×10-5). Conclusion: Hepatic IL32 is overexpressed in NAFLD, correlates with hepatic fat and liver damage, and is detectable in the circulation, where it is independently associated with the presence and severity of NAFLD. © 2020 American Medical Association. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a cytokines | |
| 653 | a genetics | |
| 653 | a nonalcoholic steatohepatitis | |
| 653 | a RNA expression | |
| 700 | 1 | a Dongiovanni, P.4 aut |
| 700 | 1 | a Rametta, R.4 aut |
| 700 | 1 | a Meroni, M.4 aut |
| 700 | 1 | a Pelusi, S.4 aut |
| 700 | 1 | a Maggioni, M.4 aut |
| 700 | 1 | a Badiali, S.4 aut |
| 700 | 1 | a Pingitore, P.4 aut |
| 700 | 1 | a Maurotti, S.4 aut |
| 700 | 1 | a Montalcini, T.4 aut |
| 700 | 1 | a Taliento, A. E.4 aut |
| 700 | 1 | a Prati, D.4 aut |
| 700 | 1 | a Rossi, G.4 aut |
| 700 | 1 | a Fracanzani, A. L.4 aut |
| 700 | 1 | a Mancina, Rosellina Margheritau Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine4 aut0 (Swepub:gu)xmanro |
| 700 | 1 | a Romeo, Stefano,d 1976u Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory4 aut0 (Swepub:gu)xroste |
| 700 | 1 | a Valenti, L.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för medicin, avdelningen för molekylär och klinisk medicin4 org |
| 773 | 0 | t Gutd : BMJg 69, s. 1855-1866q 69<1855-1866x 0017-5749x 1468-3288 |
| 856 | 4 | u https://gut.bmj.com/content/gutjnl/69/10/1855.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/294163 |
| 856 | 4 8 | u https://doi.org/10.1136/gutjnl-2019-319226 |
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Baselli, G. A.
- Dongiovanni, P.
- Rametta, R.
- Meroni, M.
- Pelusi, S.
- Maggioni, M.
- visa fler...
- Badiali, S.
- Pingitore, P.
- Maurotti, S.
- Montalcini, T.
- Taliento, A. E.
- Prati, D.
- Rossi, G.
- Fracanzani, A. L ...
- Mancina, Roselli ...
- Romeo, Stefano, ...
- Valenti, L.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Medicinska och f ...
- och Medicinsk geneti ...
- Artiklar i publikationen
- Gut
- Av lärosätet
- Göteborgs universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
