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Describing the stat...
Describing the status of reproductive ageing simply and precisely: A reproductive ageing score based on three questions and validated with hormone levels
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- Triebner, K. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway; Univ Bergen, Core Facil Metabol, Bergen, Norway
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- Johannessen, A. (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway; Haukeland Hosp, Dept Occupat Med, Bergen, Norway
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- Svanes, C. (författare)
- Univ Bergen, Dept Global Publ Hlth & Primary Care, Ctr Int Hlth, Bergen, Norway; Haukeland Hosp, Dept Occupat Med, Bergen, Norway
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- Leynaert, B. (författare)
- INSERM, UMR1152, Team Epidemiol, Paris, France
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- Benediktsdottir, B. (författare)
- Univ Iceland, Fac Med, Reykjavik, Iceland
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- Demoly, P. (författare)
- Univ Hosp Montpellier, Div Allergy, Dept Pulmonol, Montpellier, France
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- Dharmage, S. C. (författare)
- Univ Melbourne, Melbourne Sch Populat Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia
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- Franklin, Karl A (författare)
- Umeå universitet,Kirurgi
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- Heinrich, J. (författare)
- Univ Melbourne, Melbourne Sch Populat Hlth, Allergy & Lung Hlth Unit, Melbourne, Vic, Australia; Ludwig Maximilians Univ Munchen, Inst & Outpatient Clin Occupat Social & Environm, Munich, Germany
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- Holm, Mathias, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine,Gothenburg Univ, Dept Occupat & Environm Med, Gothenburg, Sweden
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- Jarvis, D. (författare)
- Imperial Coll, Dept Resp Epidemiol Occupat Med & Publ Hlth, London, England
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- Lindberg, Eva (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Rovira, J. M. M. (författare)
- Serv Salud Castilla La Mancha, Serv Neumol, Albacete, Spain
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- Agirre, N. M. (författare)
- Gobierno Vasco, Dept Salud, Salud Publ, Epidemiol, Galdakao, Spain
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- Sanchez-Ramos, J. L. (författare)
- Univ Huelva, Dept Nursing, Huelva, Spain
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- Schlunssen, V. (författare)
- Aarhus Univ, Dept Publ Hlth, Aarhus, Denmark; Natl Res Ctr Working Environm, Copenhagen, Denmark
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- Skulstad, S. M. (författare)
- Haukeland Hosp, Dept Occupat Med, Bergen, Norway
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- Hustad, S. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway; Univ Bergen, Core Facil Metabol, Bergen, Norway
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- Rodriguez, F. J. (författare)
- Univ Malaga, Dept Appl Math, Malaga, Spain
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- Real, F. G. (författare)
- Univ Bergen, Dept Clin Sci, Bergen, Norway; Haukeland Hosp, Dept Gynecol & Obstet, Bergen, Norway
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(creator_code:org_t)
- 2020-06-30
- 2020
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 15:6
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Equation 6. Quadratic logistic function approximating the function mu(B)(with age in years). Equation 1. Proportion of women who have regular menstruation for each number of reported menstruations in the last year(with period = number of periods per year, x = number of women answering "Yes" to the question: "Do you have regular periods?", y = number of women answering "No, they have been irregular for a few months" and z = number of women answering "No, my periods have stopped", e.g. x(11) = number of women reporting regular menstruation among those who report 11 menstruations in the last 12 months). Equation 5. Biquadratic exponential function mu(A)depending of the number of periods. Equation 3. Age modification by smoking and oophorectomy. Equation 2. Proportion of women whose menstruations have already stopped, for each reported year of age(with age = age in years, x = number of women answering "Yes" to the question: "Do you have regular periods?", y = number of women answering "No, they have been irregular for a few months", z = number of women answering "No, my periods have stopped", e.g. x(40) = number of women reporting regular menstruations among those who are 40 years old). Equation 7. Final formula to calculate the reproductive ageing score (RAS)(with period being the number of periods per year and age as the age in years, modified according to smoking status and oophorectomy). Objective Most women live to experience menopause and will spend 4-8 years transitioning from fertile age to full menstrual stop. Biologically, reproductive ageing is a continuous process, but by convention, it is defined categorically as pre-, peri- and postmenopause; categories that are sometimes supported by measurements of sex hormones in blood samples. We aimed to develop and validate a new tool, a reproductive ageing score (RAS), that could give a simple and yet precise description of the status of reproductive ageing, without hormone measurements, to be used by health professionals and researchers. Methods Questionnaire data on age, menstrual regularity and menstrual frequency was provided by the large multicentre population-based RHINE cohort. A continuous reproductive ageing score was developed from these variables, using techniques of fuzzy mathematics, to generate a decimal number ranging from 0.00 (nonmenopausal) to 1.00 (postmenopausal). The RAS was then validated with sex hormone measurements (follicle stimulating hormone and 17 beta-estradiol) and interview-data provided by the large population-based ECRHS cohort, using receiver-operating characteristics (ROC). Results The RAS, developed from questionnaire data of the RHINE cohort, defined with high precision and accuracy the menopausal status as confirmed by interview and hormone data in the ECRHS cohort. The area under the ROC curve was 0.91 (95% Confidence interval (CI): 0.90-0.93) to distinguish nonmenopausal women from peri- and postmenopausal women, and 0.85 (95% CI: 0.83-0.88) to distinguish postmenopausal women from nonmenopausal and perimenopausal women. Conclusions The RAS provides a useful and valid tool for describing the status of reproductive ageing accurately, on a continuous scale from 0.00 to 1.00, based on simple questions and without requiring blood sampling. The score allows for a more precise differentiation than the conventional categorisation in pre-, peri- and postmenopause. This is useful for epidemiological research and clinical trials. Equation 4. The reproductive ageing score as an aggregation function of mu(A)and mu(B).
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- quality-of-life
- menopause transition
- unfinished agenda
- menstrual
- cycles
- Science & Technology - Other Topics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Triebner, K.
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Johannessen, A.
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Svanes, C.
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Leynaert, B.
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Benediktsdottir, ...
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Demoly, P.
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visa fler...
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Dharmage, S. C.
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Franklin, Karl A
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Heinrich, J.
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Holm, Mathias, 1 ...
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Jarvis, D.
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Lindberg, Eva
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Rovira, J. M. M.
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Agirre, N. M.
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Sanchez-Ramos, J ...
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Schlunssen, V.
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Skulstad, S. M.
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Hustad, S.
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Rodriguez, F. J.
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Real, F. G.
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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