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Multi-cohort profil...
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease
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- Bergström, Sofia (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Division of Affinity Proteomics Department of Protein Science SciLifeLab KTH Royal Institute of Technology Stockholm Sweden
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- Remnestål, Julia (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Division of Affinity Proteomics Department of Protein Science SciLifeLab KTH Royal Institute of Technology Stockholm Sweden
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- Yousef, Jamil (författare)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab,Division of Affinity Proteomics Department of Protein Science SciLifeLab KTH Royal Institute of Technology Stockholm Sweden
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visa fler...
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- Olofsson, Jennie (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Division of Affinity Proteomics Department of Protein Science SciLifeLab KTH Royal Institute of Technology Stockholm Sweden
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- Markaki, I. (författare)
- Karolinska Institutet,Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
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- Carvalho, S. (författare)
- Sorbonne Université Institut du Cerveau ‐ Paris Brain Institute ‐ ICM, Assistance‐Publique Hôpitaux de Paris INSERM CNRS Hôpital Pitié‐Salpêtrière Department of Neurology Centre d’Investigation Clinique Neurosciences Paris France
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- Corvol, J. C. (författare)
- Sorbonne Université Institut du Cerveau ‐ Paris Brain Institute ‐ ICM, Assistance‐Publique Hôpitaux de Paris INSERM CNRS Hôpital Pitié‐Salpêtrière Department of Neurology Centre d’Investigation Clinique Neurosciences Paris France
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- Kultima, Kim (författare)
- Uppsala universitet,Klinisk kemi,Institutionen för farmaceutisk biovetenskap,Cancerfarmakologi och beräkningsmedicin
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- Kilander, Lena (författare)
- Uppsala universitet,Geriatrik
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- Löwenmark, Malin, 1969- (författare)
- Uppsala universitet,Geriatrik
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- Ingelsson, Martin (författare)
- Uppsala universitet,Geriatrik
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- Blennow, Kaj, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy University of Gothenburg;Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden
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- Zetterberg, Henrik, 1973 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology,Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology The Sahlgrenska Academy University of Gothenburg;Clinical Neurochemistry Laboratory Sahlgrenska University Hospital Mölndal Sweden;Department of Neurodegenerative Disease UCL Institute of Neurology London UK;UK Dementia Research Institute at UCL London UK
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- Nellgård, Bengt, 1956 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för anestesiologi och intensivvård,Institute of Clinical Sciences, Department of Anesthesiology and Intensive care,Anesthesiology and Intensive Care Medicine Sahlgrenska University Hospital Mölndal Sweden;Department of Anesthesiology and Intensive Care Medicine Institute of Clinical Sciences The Sahlgrenska Academy University of Gothenburg
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- Brosseron, F. (författare)
- Universitätsklinikum Bonn Germany;German Center for Neurodegenerative Diseases (DZNE) Bonn Germany
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- Heneka, M. T. (författare)
- Universitätsklinikum Bonn Germany
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- Bosch, B. (författare)
- Alzheimer’s and other cognitive disorders Unit. Service of Neurology Hospital Clínic de Barcelona Institut d'Investigació Biomèdica August Pi i Sunyer University of Barcelona Barcelona Spain
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- Sanchez-Valle, R. (författare)
- Alzheimer’s and other cognitive disorders Unit. Service of Neurology Hospital Clínic de Barcelona Institut d'Investigació Biomèdica August Pi i Sunyer University of Barcelona Barcelona Spain
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- Månberg, Anna, 1985- (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Division of Affinity Proteomics Department of Protein Science SciLifeLab KTH Royal Institute of Technology Stockholm Sweden
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- Svenningsson, P. (författare)
- Karolinska Institutet,Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
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- Nilsson, Peter (författare)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik,Division of Affinity Proteomics Department of Protein Science SciLifeLab KTH Royal Institute of Technology Stockholm Sweden
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(creator_code:org_t)
- 2021-06-15
- 2021
- Engelska.
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Ingår i: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 8:7, s. 1456-1470
- Relaterad länk:
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https://onlinelibrar...
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Objective: Decreased amyloid beta (A beta) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages. Methods: We utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification. Results: Six proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A beta 42 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations. Interpretation: In conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- serum neurofilament light
- mild cognitive impairment
- cerebrospinal-fluid
- plasma biomarkers
- pathology
- neurodegeneration
- amphiphysin
- association
- determinant
- proteomics
- Neurosciences & Neurology
- Alzheimers disease
- Bioteknologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Bergström, Sofia
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Remnestål, Julia
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Yousef, Jamil
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Olofsson, Jennie
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Markaki, I.
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Carvalho, S.
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visa fler...
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Corvol, J. C.
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Kultima, Kim
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Kilander, Lena
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Löwenmark, Malin ...
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Ingelsson, Marti ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Nellgård, Bengt, ...
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Brosseron, F.
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Heneka, M. T.
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Bosch, B.
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Sanchez-Valle, R ...
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Månberg, Anna, 1 ...
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Svenningsson, P.
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Nilsson, Peter
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Annals of Clinic ...
- Av lärosätet
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Göteborgs universitet
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Kungliga Tekniska Högskolan
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Karolinska Institutet
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Uppsala universitet