SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/324906"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/324906" > Is sibship composit...

  • Lisik, DaniilGothenburg University,Göteborgs universitet,Krefting Research Centre (författare)

Is sibship composition a risk factor for childhood asthma? Systematic review and meta-analysis

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/324906
  • https://gup.ub.gu.se/publication/324906URI
  • https://doi.org/10.1007/s12519-023-00706-wDOI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Following the "hygiene hypothesis", the role of sibship composition in asthma and wheezing has been extensively studied, but the findings are inconsistent. For the first time, this systematic review and meta-analysis synthesized evidences from studies investigating the association of sibship size and birth order with risk of asthma and wheezing.Fifteen databases were searched to identify eligible studies. Study selection and data extraction were performed independently by pairs of reviewers. Meta-analysis with robust variance estimation (RVE) was used to produce pooled risk ratio (RR) effect estimates from comparable numerical data.From 17,466 identified records, 158 reports of 134 studies (>3 million subjects) were included. Any wheezing in the last≤1.5years occurred more frequently in infants with≥1 sibling [pooled RR 1.10, 95% confidence interval (CI) 1.02-1.19] and≥1 older sibling (pooled RR 1.16, 95% CI 1.04-1.29). The pooled effect sizes for asthma were overall statistically nonsignificant, although having≥1 older sibling was marginally protective for subjects aged≥6years (pooled RR 0.93, 95% CI 0.88-0.99). The effect estimates weakened in studies published after 2000 compared with earlier studies.Being second-born or later and having at least one sibling is associated with a slightly increased risk of temporary wheezing in infancy. In contrast, being second-born or later is associated with marginal protection against asthma. These associations appear to have weakened since the turn of the millennium, possibly due to lifestyle changes and socioeconomic development. Video Abstract.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ermis, Özuygur,1991Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xozusa (författare)
  • Ioannidou, AthinaGothenburg University,Göteborgs universitet,Krefting Research Centre (författare)
  • Milani, Gregorio Paolo (författare)
  • Nyassi, SungkutuGothenburg University,Göteborgs universitet,Krefting Research Centre (författare)
  • Spolidoro, Giulia Carla Immacolata (författare)
  • Kankaanranta, Hannu,1967Gothenburg University,Göteborgs universitet,Krefting Research Centre(Swepub:gu)xkankh (författare)
  • Goksör, Emma,1974Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xgokem (författare)
  • Wennergren, Göran,1947Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Krefting Research Centre,Institute of Clinical Sciences, Department of Pediatrics(Swepub:gu)xwengo (författare)
  • Nwaru, Bright I,1978Gothenburg University,Göteborgs universitet,Krefting Research Centre,Wallenberg Centre for Molecular and Translational Medicine(Swepub:gu)xnwabr (författare)
  • Göteborgs universitetKrefting Research Centre (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:World journal of pediatrics : WJP19:12, s. 1127-381867-0687

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy