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Fracture Incidence ...
Fracture Incidence in Graves' Disease: A Population-Based Study.
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- Khamisi, Selwan (författare)
- Uppsala University,Uppsala University Hospital
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- Udumyan, Ruzan, 1971- (författare)
- Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län
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- Sjölin, Gabriel, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Örebro University Hospital
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- Calissendorff, Jan (författare)
- Karolinska Institutet,Karolinska Institute
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- Nyström, Helena Filipsson, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition,Sahlgrenska Academy, 70712, Dept. of Endocrinology, Sahlgrenska University Hospital, Goteborg, Sweden
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- Holmberg, Mikael, 1950 (författare)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Hallengren, Bengt (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Lantz, Mikael (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Planck, Tereza (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital
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- Wallin, Göran, 1952- (författare)
- Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Karolinska Institutet, 27106, Department of Molecular Medicine and Surgery, Stockholm, Sweden; Departgment of Surgery
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- Ljunggren, Östen (författare)
- Uppsala University
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- Holmberg, Mats (författare)
- Sahlgrenska Academy, 70712, Goteborg, Sweden
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(creator_code:org_t)
- Mary Ann Liebert, 2023
- 2023
- Engelska.
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Ingår i: Thyroid : official journal of the American Thyroid Association. - : Mary Ann Liebert. - 1557-9077 .- 1050-7256. ; 33:11, s. 1349-1357
- Relaterad länk:
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http://dx.doi.org/10...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: Population-based studies have indicated an increase in bone turnover in hyperthyroidism with a subsequent decrease in bone mineral density and an increased risk of fractures, especially in postmenopausal women. However, heterogeneity between studies prevents a definitive conclusion. Graves' disease (GD) is an autoimmune disease, and it is the most common cause of hyperthyroidism. The aim of this study was to investigate fracture risk in patients with GD. Methods: A total of 2134 patients with incident GD and 21,261 age, sex- and county-matched controls were included 16-18 years after diagnosis in a retrospective cohort study. Drug and patient national registries in Sweden were used to assess the risk of developing skeletal complications. Up to 10 years of age, sex- and county-matched controls per patient were selected from databases from the National Board of Health and Welfare and Statistics Sweden. Cox proportional hazards models were fitted to estimate hazard ratios (HR) and confidence intervals [CI]. Results: There were no significant differences in fracture rates between GD and controls but after adjustment for comorbidities, the data showed higher vertebral fracture rates in male GD patients aged >52 years compared to male controls, HR=2.83 [CI 1.05-7.64]. The rates of osteoporosis treatments as well as treatment with corticosteroids were higher in patients with GD. However, HR for the association between GD and fractures remained largely unchanged after adjustment for osteoporosis treatments and treatments with corticosteroids. Conclusions: There were no significant differences in total fracture rate between GD and the general population. However, men older than 52 years had a higher vertebral fracture rate. This study also shows that patients with treated GD receive more osteoporosis treatments compared to the general population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- Humans
- Male
- Female
- Spinal Fractures
- complications
- Incidence
- Retrospective Studies
- Fractures
- Bone
- epidemiology
- etiology
- Graves Disease
- complications
- drug therapy
- epidemiology
- Hyperthyroidism
- complications
- Osteoporosis
- complications
- epidemiology
- Adrenal Cortex Hormones
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Khamisi, Selwan
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Udumyan, Ruzan, ...
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Sjölin, Gabriel, ...
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Calissendorff, J ...
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Nyström, Helena ...
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Holmberg, Mikael ...
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Hallengren, Beng ...
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Lantz, Mikael
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Planck, Tereza
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Wallin, Göran, 1 ...
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Ljunggren, Östen
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Holmberg, Mats
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Thyroid : offici ...
- Av lärosätet
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Göteborgs universitet
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Örebro universitet
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Lunds universitet
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Karolinska Institutet