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Sökning: onr:"swepub:oai:gup.ub.gu.se/337781" > Subtypes of brain c...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003747naa a2200397 4500
001oai:gup.ub.gu.se/337781
003SwePub
008240528s2024 | |||||||||||000 ||eng|
0247 a https://gup.ub.gu.se/publication/3377812 URI
0247 a https://doi.org/10.1101/2024.03.04.5832912 DOI
040 a (SwePub)gu
041 a eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Capogna, Elettra4 aut
2451 0a Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers.
264 1c 2024
520 a Structural brain changes underly cognitive changes in older age and contribute to inter-individual variability in cognition. Here, we assessed how changes in cortical thickness, surface area, and subcortical volume, are related to cognitive change in cognitively unimpaired older adults using structural magnetic resonance imaging (MRI) data-driven clustering. Specifically, we tested (1) which brain structural changes over time predict cognitive change in older age (2) whether these are associated with core cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers phosphorylated tau (p-tau) and amyloid-β (Aβ42), and (3) the degree of overlap between clusters derived from different structural features. In total 1899 cognitively healthy older adults (50 - 93 years) were followed up to 16 years with neuropsychological and structural MRI assessments, a subsample of which (n = 612) had CSF p-tau and Aβ42 measurements. We applied Monte-Carlo Reference-based Consensus clustering to identify subgroups of older adults based on structural brain change patterns over time. Four clusters for each brain feature were identified, representing the degree of longitudinal brain decline. Each brain feature provided a unique contribution to brain aging as clusters were largely independent across modalities. Cognitive change and baseline cognition were best predicted by cortical area change, whereas higher levels of p-tau and Aβ42 were associated with changes in subcortical volume. These results provide insights into the link between changes in brain morphology and cognition, which may translate to a better understanding of different aging trajectories.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
7001 a Sørensen, Øystein4 aut
7001 a Watne, Leiv Otto4 aut
7001 a Roe, James4 aut
7001 a Strømstad, Marie4 aut
7001 a Idland, Ane Victoria4 aut
7001 a Halaas, Nathalie Bodd4 aut
7001 a Blennow, Kaj,d 1958u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xbleka
7001 a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe
7001 a Walhovd, Kristine Beate4 aut
7001 a Fjell, Anders Martin4 aut
7001 a Vidal-Piñeiro, Didac4 aut
7102 a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
7730 t bioRxiv : the preprint server for biology
8564 8u https://gup.ub.gu.se/publication/337781
8564 8u https://doi.org/10.1101/2024.03.04.583291

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