Bet v 1-specific IgA increases during the pollen season but not after a single allergen challenge in children with birch pollen-induced intermittent allergic rhinitis

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Keen, ChristinaGothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden (författare)

Bet v 1-specific IgA increases during the pollen season but not after a single allergen challenge in children with birch pollen-induced intermittent allergic rhinitis

Artikel/kapitelEngelska2005

Förlag, utgivningsår, omfång ...

Wiley-Blackwell,2005

Nummerbeteckningar

LIBRIS-ID:oai:gup.ub.gu.se/53283
https://gup.ub.gu.se/publication/53283URI
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-98558URI
https://doi.org/10.1111/j.1399-3038.2005.00264.xDOI

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Språk:engelska

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Ämneskategori:art swepub-publicationtype

Anmärkningar

Allergen-specific immunoglobulins of the Immunoglobulin A (IgA) type have been found in the nasal fluid of patients with allergic rhinitis. IgA may play a protective role, but there are also data which show that allergen-specific IgA can induce eosinophil degranulation. The aim of this study was to quantitate Bet v 1-specific IgA in relation to total IgA in the nasal fluid of children with birch pollen-induced intermittent allergic rhinitis and healthy controls, after allergen challenge and during the natural pollen season. Eosinophil cationic protein (ECP), Bet v 1-specific IgA and total IgA were analyzed in nasal fluids from 30 children with birch pollen-induced intermittent allergic rhinitis and 30 healthy controls. Samples were taken before the pollen season, after challenge with birch pollen and during the pollen season, before and after treatment with nasal steroids. During the pollen season, but not after nasal allergen challenge, Bet v 1-specific IgA increased in relation to total IgA in children with allergic rhinitis. No change was found in the healthy controls. The ratio of Bet v 1-specific IgA to total IgA increased from 0.1 x 10(-3) (median) to 0.5 x 10(-3) in the allergic children, p < 0.001. No change was seen after treatment with nasal steroids, although symptoms, ECP and eosinophils were reduced. In conclusion, allergen-specific IgA in relation to total IgA increases in nasal fluids during the pollen season in allergic children but not in healthy controls. These findings are compatible with the hypothesis that allergen-specific IgA plays a role in the allergic inflammation and further studies are needed to clarify the functional role of these allergen-specific antibodies.

Ämnesord och genrebeteckningar

Adolescent
Allergens/administration & dosage/adverse effects/*immunology
Anti-Inflammatory Agents/therapeutic use
*Antibody Specificity
Betula/adverse effects/immunology
Budesonide/therapeutic use
Child
Hay Fever/drug therapy/etiology/*immunology
Humans
Immunoglobulin A/*blood
Nasal Lavage Fluid/immunology
Nasal Mucosa/*immunology
Nasal Provocation Tests
Plant Proteins/*immunology
Pollen/*adverse effects/immunology
Research Support
Non-U.S. Gov't
Seasons
allergen-specific IgA; allergic rhinitis; children; nasal secretions

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johansson, S.Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden (författare)
Reinholdt, J.Department of Oral Biology, Royal Dental College, Aarhus, Denmark (författare)
Benson, Mikael,1954Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden(Swepub:liu)mikbe05 (författare)
Wennergren, Göran,1947Gothenburg University,Göteborgs universitet,Institutionen för kvinnors och barns hälsa, Avdelningen för pediatrik,Institute for the Health of Women and Children, Dept of Paediatrics,Department of Pediatrics, Göteborg University, Göteborg, Sweden(Swepub:gu)xwengo (författare)
Göteborgs universitetInstitutionen för kvinnors och barns hälsa, Avdelningen för pediatrik (creator_code:org_t)

Sammanhörande titlar

Ingår i:Pediatr Allergy Immunol: Wiley-Blackwell16:3, s. 209-160905-61571399-3038

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Av författaren/redakt...: Keen, Christina; Johansson, S.; Reinholdt, J.; Benson, Mikael, ...; Wennergren, Göra ...

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Av lärosätet: Göteborgs universitet; Linköpings universitet

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