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Nonrandom pattern o...
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Adamovic, Tatjana,1974Högskolan i Skövde,Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, genetik,Department of Cell and Molecular Biology, Genetics,Institutionen för teknik och samhälle
(författare)
Nonrandom pattern of chromosome aberrations in 17beta-estradiol-induced rat mammary tumors: indications of distinct pathways for tumor development.
- Artikel/kapitelEngelska2007
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LIBRIS-ID:oai:gup.ub.gu.se/54227
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https://gup.ub.gu.se/publication/54227URI
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https://doi.org/10.1002/gcc.20428DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-1991URI
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Tatjana AdamovicCMB-Genetics, Göteborg University, SE 40530 Göteborg,SwedenDepartmentof Clinical Genetics, Göteborg University, SE 40530 Göteborg, Sweden
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Estrogens play an important role in breast cancer etiology and the ACI rat provides a novel animal model for defining the mechanisms through which estrogens contribute to mammary cancer development. In crossing experiments between the susceptible ACI strain and two resistant strains, COP (Copenhagen) and BN (Brown Norway), several quantitative trait loci (QTL) that affect development of 17beta-estradiol (E2)-induced mammary tumors have been defined. Using comparative genomic hybridization (CGH), we have analyzed cytogenetic aberrations in E2-induced mammary cancers and have found clear patterns of nonrandom chromosomal involvement. Approximately two thirds of the tumors exhibited copy number changes. Losses of rat chromosome 5 (RNO5) and RNO20 were particularly common, and it was found that these two aberrations often occurred together. A third recurrent aberration involving proximal gain and distal loss in RNO6 probably defined a distinct subgroup of tumors, since it never occurred in combination with RNO5 loss. Interestingly, QTL with powerful effects on mammary cancer development have been mapped to RNO5 and RNO6. These findings suggest that there were at least two genetic pathways to tumor formation in this rat model of E2-induced mammary cancer. By performing CGH on mammary tumors from ACI rats, F1 rats from crosses between the ACI and COP or BN strains and ACI.BN-Emca8 congenic rats, which carry the BN allele of the Emca8 QTL on RNO5 on the ACI genetic background, we were able to determine that the constitution of the germ line influences the pattern of chromosomal aberrations.
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Roshani, Leyla,1972Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,CMB-Genetics, Göteborg University, SE 40530 Göteborg, Sweden / Department of Clinical Genetics, Göteborg University, SE 40530 Göteborg, Sweden(Swepub:gu)xrosle
(författare)
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Chen, LeiHögskolan i Skövde,Institutionen för kommunikation och information
(författare)
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Schaffer, Beverly SDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, United States / Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, United States
(författare)
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Helou, Khalil,1966Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper,Institute of Clinical Sciences,Department of Oncology, Göteborg University, Sahlgrenska University, Göteborg, Sweden(Swepub:gu)xhelkh
(författare)
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Levan, Göran,1939Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,CMB-Genetics, Göteborg University, SE 40530 Göteborg, Sweden / Department of Clinical Genetics, Göteborg University, SE 40530 Göteborg, Sweden(Swepub:gu)xlevag
(författare)
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Olsson, BjörnHögskolan i Skövde,Institutionen för kommunikation och information(Swepub:his)olsb
(författare)
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Shull, James DDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, United States / Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, NE 68198, United States / Department of Genetics, Cell Biology and Anatomy, 6005 Durham Research Center, 985805 Nebraska Medical Center, Omaha, NE 68198-5805, United States
(författare)
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Göteborgs universitetInstitutionen för cell- och molekylärbiologi, genetik
(creator_code:org_t)
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Ingår i:Genes, chromosomes & cancer: Wiley46:5, s. 459-691045-22571098-2264
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