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Sökning: onr:"swepub:oai:gup.ub.gu.se/56077" > Impact of age on le...

  • Gerdts, E. (författare)

Impact of age on left ventricular hypertrophy regression during antihypertensive treatment with losartan or atenolol (the LIFE study)

  • Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

  • 2004

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/56077
  • https://gup.ub.gu.se/publication/56077URI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • To assess the influence of age on changes in left ventricular (LV) mass and geometry during antihypertensive treatment, we related age to clinical and echocardiographic findings before and after 4 years of antihypertensive treatment in a subset of 560 hypertensive patients without known concurrent disease in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study, which randomized patients to blinded losartan- or atenolol-based treatment. Patients >/=65 years (older group) included more women and patients with isolated systolic hypertension or albuminuria (all P<0.05). Compared to patients <65 years, older patients had higher pulse pressure, LV mass, and prevalence of concentric hypertrophy at baseline (78 vs 69 mmHg, 234 vs 224 g, and 28 vs 16%, respectively, all P<0.01), while the mean blood pressure did not differ. Over 4 years, reductions in LV mass and the mean blood pressure were similar in both groups, but older patients more often had residual hypertrophy (31 vs 15%, P<0.001) with a preponderance of eccentric geometry. In multivariate analysis of 4-year change in LV mass controlling for baseline mass, larger hypertrophy reduction was associated with losartan treatment, while age, gender, body mass index, and 4-year change in pulse pressure and albuminuria did not enter (Multiple R (2)=0.40, P<0.001). Thus, in up-to-80-year-old hypertensive patients with left ventricular hypertrophy, age did not significantly attenuate hypertrophy reduction during antihypertensive treatment, although residual hypertrophy was more prevalent in older patients as a consequence of higher initial LV mass.

Ämnesord och genrebeteckningar

  • Age Factors
  • Aged
  • Aged
  • 80 and over
  • Antihypertensive Agents/*therapeutic use
  • Atenolol/*therapeutic use
  • Female
  • Follow-Up Studies
  • Heart Ventricles/ultrasonography
  • Humans
  • Hypertension/drug therapy
  • Hypertrophy
  • Left Ventricular/drug therapy/*ultrasonography
  • Losartan/*therapeutic use
  • Male
  • Middle Aged
  • Remission Induction
  • Time Factors

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Roman, M. J. (författare)
  • Palmieri, V. (författare)
  • Wachtell, K. (författare)
  • Smith, G. (författare)
  • Nieminen, M. S. (författare)
  • Dahlöf, Björn,1953Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute(Swepub:gu)xdahbj (författare)
  • Devereux, R. B. (författare)
  • Göteborgs universitetHjärt-kärlinstitutionen (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:J Hum Hypertens18:6, s. 417-220950-9240

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