SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:gup.ub.gu.se/62938"
 

Sökning: onr:"swepub:oai:gup.ub.gu.se/62938" > Complement activati...

  • Soop, A (författare)

Complement activation, endothelin-1 and neuropeptide Y in relation to the cardiovascular response to endotoxin-induced systemic inflammation in healthy volunteers.

  • Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

  • Wiley,2004

Nummerbeteckningar

  • LIBRIS-ID:oai:gup.ub.gu.se/62938
  • https://gup.ub.gu.se/publication/62938URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1930393URI
  • https://doi.org/10.1111/j.1399-6576.2004.00273.xDOI

Kompletterande språkuppgifter

  • Språk:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: Endotoxin is a major stimulus for triggering the host response in septicaemia. The pathophysiology of sepsis involves activation of the vascular endothelium and leukocytes, resulting in the release of various mediators, e.g. cytokines, nitric oxide (NO), endothelin (ET-1) and complement factors. We evaluated the blood levels of complement activation, ET-1 and neuropeptide Y (NPY) in parallel with the haemodynamic and oxygen transport response during human experimental endotoxemia. METHODS: Eleven healthy men had venous, arterial and pulmonary arterial catheters placed for continuous haemodynamic measuring. After 30 min rest endotoxin (E. Coli 4 ng kg(-1), Lot G1) was intravenously administered. Blood samples from pulmonary and arterial catheters were collected hourly over 4 h. RESULTS: Body temperature augmented significantly from baseline values (36.7 +/- 0.7 degrees C, mean +/- SEM) with a maximum after 3.5 h (39.1 +/- 0.3 degrees C, P < 0.001). Cardiac output increased by 100%, systemic vascular resistance decreased by 50%, the oxygen consumption and the tissue oxygen transport increased. Activation of the complement system was indicated by an increase in SC5b-9. Endothelin-1-like immunoreactivity (ET-1-LI) increased over time in arterial blood. NPY-like immunoreactivity (NPY-LI) did not change over time. CONCLUSION: A dose of endotoxin associated with reproducible systemic vasodilation and fever in healthy subjects causes complement activation and increased systemic levels of ET-1-LI, illustrating that the model is a useful tool for inducing moderate systemic inflammation where several mediator systems are activated.

Ämnesord och genrebeteckningar

  • Adult
  • Body Temperature
  • drug effects
  • Complement Activation
  • physiology
  • Endothelin-1
  • blood
  • Endotoxemia
  • physiopathology
  • Endotoxins
  • Hemodynamics
  • physiology
  • Humans
  • Inflammation
  • chemically induced
  • physiopathology
  • Male
  • Neuropeptide Y
  • blood
  • Oxygen Consumption
  • drug effects
  • Pulmonary Alveoli
  • metabolism
  • physiology
  • Pulmonary Gas Exchange
  • drug effects

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Albert, JKarolinska Institutet (författare)
  • Weitzberg, EKarolinska Institutet (författare)
  • Bengtsson, Anders,1954Gothenburg University,Göteborgs universitet,Institutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård,Institute of Surgical Sciences, Department of Anaesthesiology and Intensive Care(Swepub:gu)xbeand (författare)
  • Lundberg, J O NKarolinska Institutet (författare)
  • Sollevi, AKarolinska Institutet (författare)
  • Karolinska InstitutetInstitutionen för de kirurgiska disciplinerna, Avdelningen för anestesiologi och intensivvård (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Acta anaesthesiologica Scandinavica: Wiley48:1, s. 74-810001-5172

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy