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The functional sign...
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Behboudi, Afrouz,1967Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden
(författare)
The functional significance of absence: the chromosomal segment harboring Tp53 is absent from the T55 rat radiation hybrid mapping panel.
- Artikel/kapitelEngelska2002
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LIBRIS-ID:oai:gup.ub.gu.se/68435
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https://gup.ub.gu.se/publication/68435URI
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https://doi.org/10.1006/geno.2002.6785DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-23013URI
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We thank Khalil Helou (Department of Oncology, Sahlgrenska Hospital, Göteborg, Sweden) for valuable remarks on FISH results. The D10Ncc3 marker plasmid was kindly provided by Toshikazu Ushijima (National Cancer Center Research Institute, Tokyo, Japan). This work was supported by grants from the Swedish Medical Research Council, the Wallenberg Foundation, the Erik Philip-Sörensen Foundation, the Carl Trygger Foundation, the IngaBritt and Arne Lundberg Research Foundation, the Royal Swedish Academy of Sciences, the Wilhelm and Martina Lundgren Foundation, and the Royal and Hvitfeldtska Foundation.
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The T55 rat radiation hybrid (RH) mapping panel has been reported to retain the entire rat genome at retention frequencies between 22% and 37%. However, we found that a small segment of rat chromosome 10 harboring at least four different genes, including Tp53, was completely absent from the panel (retention frequency = 0%). Two other markers located in the vicinity exhibited much reduced retention (2-6%). RH clones are generated by transferring highly fragmented DNA into a recipient cell. There might be a strong selection against the transfer and retention of chromosome segments harboring an intact Tp53, as the action of this gene might prevent proliferation and establishment of the RH clone. Our finding further suggests that unexpected low retention or absence of chromosome segments in an RH panel may represent indications that the segments harbor genes with important functions in cell proliferation control.
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Roshani, Leyla,1972Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:gu)xrosle
(författare)
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Lundin, LisaGothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden
(författare)
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Ståhl, Fredrik,1956Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, genetik,Department of Cell and Molecular Biology, Genetics,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:gu)xstafr
(författare)
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Klinga-Levan, Karin,1951-Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi,Department of Cell and Molecular Biology,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:his)klik
(författare)
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Levan, Göran,1939Gothenburg University,Göteborgs universitet,Institutionen för cell- och molekylärbiologi, genetik,Department of Cell and Molecular Biology, Genetics,Department of Cell and Molecular Biology-Genetics, Lundberg Laboratory, Göteborg University, Sweden(Swepub:gu)xlevag
(författare)
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Göteborgs universitetInstitutionen för cell- och molekylärbiologi
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Ingår i:Genomics: Elsevier BV79:6, s. 844-80888-75431089-8646
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