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Uricemia in juvenile pigs model : Effect of nephrectomy and potassium oxonate

Mosiichuk, N. (författare)
Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science,Vasyl Stefanyk Precarpathian National University
Grujic, D. (författare)
Allena Pharmaceuticals
Woliński, J. (författare)
The Kielanowski Institute of Animal Physiology and Nutrition of the Polish Academy of Sciences
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Podpryatov, S. E. (författare)
Kyiv Municipal Clinic
Podpriatov, S. S. (författare)
Kyiv Municipal Clinic
Szczurek, P. (författare)
National Research Institute of Animal Production
Yatsenko, T. (författare)
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
Shmihel, H. (författare)
Vasyl Stefanyk Precarpathian National University
Drahanchuk, O. (författare)
The Kielanowski Institute of Animal Physiology and Nutrition of the Polish Academy of Sciences
Pierzynowski, S. G. (författare)
Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science,Anara AB
Goncharova Pierzynowska, K. (författare)
Lund University,Lunds universitet,Funktionell zoologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Functional zoology,Department of Biology,Faculty of Science,Anara AB
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 (creator_code:org_t)
2019-08-28
2019
Engelska 9 s.
Ingår i: Journal of Animal and Feed Sciences. - : The Kielanowski Institute of Animal Physiology and Nutrition, PAS. - 1230-1388. ; 28:3, s. 254-262
Relaterad länk:
http://dx.doi.org/10... (free)
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http://www.jafs.com....
https://lup.lub.lu.s...
https://doi.org/10.2...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Uric acid is the end product of dietary and endogenous purine metabolism in humans and higher primates. In all lower mammalian species it is converted to allantoin by liver uricase. The aim of this study was to investigate the uric acid turnover in pig model after nephrectomy surgery, fructose-enriched diet and potassium oxonate application. The first experiment was performed using 4 intact control pigs and 8 nephrectomized (5/6 nephrectomy) pigs. Both groups were fed high-fat diet enriched with 20% of fructose for 3 weeks. During the second experiment, as another approach to induce hyperuricemia, potassium oxonate solution (POx) was administered intravenously to 4 healthy pigs, once or twice per day. In the third preliminary experiment one healthy and two nephrectomized (9/10 nephrectomy) pigs were infused with POx to induce hyperuricemia. Results showed that 5/6 nephrecotomy did not affect plasma uric acid concentration for 25 days following surgery. The consumption of the high-fat diet enriched with 20% of fructose did not result in the rise of plasma uric acid, either in healthy or nephrectomized pigs. Administration of POx solution to healthy and 9/10 nephrectomized pigs resulted in significantly increased plasma uric acid concentrations for 18 h and 24 h, respectively, following a single POx infusion. The present study expands today available data on uric acid metabolism in pigs as a model for exploring uricemia in human with kidney dysfunction.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)

Nyckelord

Creatinine
Fructose
Hyperuricemia
Pigs
Potassium oxonate
Uric acid

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