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Effects of luminal ...
Effects of luminal stimuli on polyamine metabolism in the small intestine of the rat : the role of enteric nerves
- Artikel/kapitelEngelska1993
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:12f2f869-b177-47dd-a6ec-83b8eeece8fb
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https://lup.lub.lu.se/record/12f2f869-b177-47dd-a6ec-83b8eeece8fbURI
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https://doi.org/10.1111/j.1748-1716.1993.tb09646.xDOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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The aim of this study was to investigate to what extent polyamine metabolism in the small intestine of the rat is controlled by the enteric nervous system. Polyamine metabolism was followed by measuring the activity of ornithine decarboxylase (ODC) and in some instances also the content of polyamines (putrescine, spermidine and spermine). ODC activity in the intestine was increased when intraluminal pressure was increased and 3 h after placing cholera toxin in the intestinal lumen. Cholera toxin also increased the tissue putrescine content. Atropine or hexamethonium given i.v. did not influence the evoked changes of ODC activity. The pressure induced changes were not decreased by placing lidocaine on the serosal surface. On the other hand, the ODC activity of control segments were decreased by hexamethonium or atropine. The presence of glucose in the intestinal perfusate did not augment tissue ODC activity, neither did the heat stable enterotoxin from Escherichia coli (STa). It is concluded that the effect on polyamine metabolism evoked by luminal pressure or cholera toxin seems not to be mediated via nerves, while nerves seem to influence ODC activity during control conditions. The experiments with enterotoxins suggest that cAMP is the intracellular second messenger controlling intestinal ODC activity.
Ämnesord och genrebeteckningar
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Animals
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Cholera Toxin
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Enteric Nervous System
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Intestine, Small
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Ornithine Decarboxylase
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Polyamines
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Pressure
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Rats
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Rats, Sprague-Dawley
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Time Factors
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nilsson, B OLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Kärlfysiologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Vascular Physiology,Lund University Research Groups(Swepub:lu)mphy-bon
(författare)
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Rosengren, E
(författare)
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Ekström, J.
(författare)
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Lundgren, O
(författare)
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Institutionen för experimentell medicinsk vetenskapMedicinska fakulteten
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Acta Physiologica Scandinavica: Wiley149:4, s. 90-4830001-67721365-201X
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