Sökning: onr:"swepub:oai:lup.lub.lu.se:1364b7bb-4325-4125-b650-c0b242a2e27d" > A generalizable dat...
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000 | 12591naa a2201057 4500 | |
001 | oai:lup.lub.lu.se:1364b7bb-4325-4125-b650-c0b242a2e27d | |
003 | SwePub | |
008 | 240705s2024 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/1364b7bb-4325-4125-b650-c0b242a2e27d2 URI |
024 | 7 | a https://doi.org/10.1093/brain/awae1182 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Baumeister, Hannahu German Center for Neurodegenerative Diseases (DZNE) Magdeburg4 aut0 (Swepub:lu)ha1752ba |
245 | 1 0 | a A generalizable data-driven model of atrophy heterogeneity and progression in memory clinic settings |
264 | 1 | c 2024 |
300 | a 14 s. | |
520 | a Memory clinic patients are a heterogeneous population representing various aetiologies of pathological aging. It is unknown if divergent spatiotemporal progression patterns of brain atrophy, as previously described in Alzheimer's disease (AD) patients, are prevalent and clinically meaningful in this group of older adults. To uncover distinct atrophy subtypes, we applied the Subtype and Stage Inference (SuStaIn) algorithm to baseline structural MRI data from 813 participants enrolled in the DELCODE cohort (mean ± SD age = 70.67 ± 6.07 years, 52% females). Participants were cognitively unimpaired (CU; n = 285) or fulfilled diagnostic criteria for subjective cognitive decline (SCD; n = 342), mild cognitive impairment (MCI; n = 118), or dementia of the Alzheimer's type (n = 68). Atrophy subtypes were compared in baseline demographics, fluid AD biomarker levels, the Preclinical Alzheimer Cognitive Composite (PACC-5), as well as episodic memory and executive functioning. PACC-5 trajectories over up to 240 weeks were examined. To test if baseline atrophy subtype and stage predicted clinical trajectories before manifest cognitive impairment, we analysed PACC-5 trajectories and MCI conversion rates of CU and SCD participants. Limbic-predominant and hippocampal-sparing atrophy subtypes were identified. Limbic-predominant atrophy first affected the medial temporal lobes, followed by further temporal and, finally, the remaining cortical regions. At baseline, this subtype was related to older age, more pathological AD biomarker levels, APOE ε4 carriership, and an amnestic cognitive impairment. Hippocampal-sparing atrophy initially occurred outside the temporal lobe with the medial temporal lobe spared up to advanced atrophy stages. This atrophy pattern also affected individuals with positive AD biomarkers and was associated with more generalised cognitive impairment. Limbic-predominant atrophy, in all and in only unimpaired participants, was linked to more negative longitudinal PACC-5 slopes than observed in participants without or with hippocampal-sparing atrophy and increased the risk of MCI conversion. SuStaIn modelling was repeated in a sample from the Swedish BioFINDER-2 cohort. Highly similar atrophy progression patterns and associated cognitive profiles were identified. Cross-cohort model generalizability, both on the subject and group level, were excellent, indicating reliable performance in previously unseen data. The proposed model is a promising tool for capturing heterogeneity among older adults at early at-risk states for AD in applied settings. The implementation of atrophy subtype- and stage-specific end-points may increase the statistical power of pharmacological trials targeting early AD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a disease heterogeneity | |
653 | a Alzeimer's disease | |
653 | a Structural MRI | |
653 | a executive function | |
653 | a episodic memory | |
700 | 1 | a Vogel, Jacob Wu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)ja8870vo |
700 | 1 | a Insel, Philip Su University of California, San Francisco4 aut0 (Swepub:lu)med-ppi |
700 | 1 | a Kleineidam, Lucau German Center for Neurodegenerative Diseases (DZNE), Bonn,University Hospital Bonn4 aut |
700 | 1 | a Wolfsgruber, Steffenu University Hospital Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Stark, Melinau University Hospital Bonn4 aut |
700 | 1 | a Gellersen, Helena Mu German Center for Neurodegenerative Diseases (DZNE) Magdeburg4 aut |
700 | 1 | a Yakupov, Renatu Otto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE) Magdeburg4 aut |
700 | 1 | a Schmid, Matthias Cu University Hospital Bonn,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Lüsebrink, Falku German Center for Neurodegenerative Diseases (DZNE) Magdeburg4 aut |
700 | 1 | a Brosseron, Fredericu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Ziegler, Gabrielu Otto von Guericke University Magdeburg4 aut |
700 | 1 | a Freiesleben, Silka Du German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Preis, Lukasu Karolinska Institute4 aut |
700 | 1 | a Schneider, Luisa-Sophieu Karolinska Institute4 aut |
700 | 1 | a Spruth, Eike Ju German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Altenstein, Slaweku German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Lohse, Andreau Karolinska Institute4 aut |
700 | 1 | a Fliessbach, Klausu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Vogt, Ina Ru German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Bartels, Claudiau University Medical Center Göttingen4 aut |
700 | 1 | a Schott, Björn Hu University Medical Center Göttingen4 aut |
700 | 1 | a Rostamzadeh, Aydau University of Cologne4 aut |
700 | 1 | a Glanz, Wenzelu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Incesoy, Enise Iu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Butryn, Michaelau German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Janowitz, Danielu Institute for Stroke and Dementia Research (ISD)4 aut |
700 | 1 | a Rauchmann, Boris-Stephanu Ludwig-Maximilian University of Munich,University of Sheffield4 aut |
700 | 1 | a Kilimann, Ingou German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Goerss, Doreenu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Munk, Matthias Hu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Hetzer, Stefanu Berlin Center for Advanced Neuroimaging4 aut |
700 | 1 | a Dechent, Peteru University of Göttingen4 aut |
700 | 1 | a Ewers, Michaelu Institute for Stroke and Dementia Research (ISD)4 aut |
700 | 1 | a Scheffler, Klausu University of Tübingen4 aut |
700 | 1 | a Wuestefeld, Anikau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)an8567wu |
700 | 1 | a Strandberg, Olofu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)teor-osn |
700 | 1 | a van Westen, Danielleu Lund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)ront-dva |
700 | 1 | a Mattsson-Carlgren, Niklasu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,Skåne University Hospital4 aut0 (Swepub:lu)med-nmn |
700 | 1 | a Janelidze, Shorenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)nkir-sje |
700 | 1 | a Stomrud, Eriku Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-esr |
700 | 1 | a Palmqvist, Sebastianu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-spa |
700 | 1 | a Spottke, Annikau German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Laske, Christophu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Teipel, Stefanu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Perneczky, Robertu German Center for Neurodegenerative Diseases (DZNE), Munich,Ludwig-Maximilian University of Munich4 aut |
700 | 1 | a Buerger, Katharinau Institute for Stroke and Dementia Research (ISD)4 aut |
700 | 1 | a Schneider, Anjau German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Priller, Josefu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Peters, Oliveru German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Ramirez, Alfredou German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Wiltfang, Jensu University Medical Center Göttingen4 aut |
700 | 1 | a Heneka, Michael Tu University of Luxembourg4 aut |
700 | 1 | a Wagner, Michaelu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Düzel, Emrahu German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Jessen, Franku German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
700 | 1 | a Berron, Davidu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,Otto von Guericke University Magdeburg,German Center for Neurodegenerative Diseases (DZNE) Magdeburg4 aut0 (Swepub:lu)da1401be |
710 | 2 | a German Center for Neurodegenerative Diseases (DZNE) Magdeburgb Institutionen för kliniska vetenskaper, Malmö4 org |
773 | 0 | t Brain : a journal of neurologyg 147:7, s. 2400-2413q 147:7<2400-2413x 1460-2156 |
856 | 4 | u http://dx.doi.org/10.1093/brain/awae118x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/1364b7bb-4325-4125-b650-c0b242a2e27d |
856 | 4 8 | u https://doi.org/10.1093/brain/awae118 |
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