Sökning: onr:"swepub:oai:lup.lub.lu.se:18eddbe6-9013-4c6a-8052-99650a731dbe" >
The effect of exerc...
-
Petersen, Astrid H.
(författare)
The effect of exercise on the absorption of inhaled human insulin via the AERx insulin diabetes management system in people with type 1 diabetes
- Artikel/kapitelEngelska2007
Förlag, utgivningsår, omfång ...
-
American Diabetes Association,2007
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:18eddbe6-9013-4c6a-8052-99650a731dbe
-
https://lup.lub.lu.se/record/654365URI
-
https://doi.org/10.2337/dc06-2589DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
OBJECTIVE - This study investigated the effect of moderate exercise on the absorption of inhaled insulin via the AERx insulin diabetes management system (iDMS). RESEARCH DESIGN AND METHODS - in this randomized, open-label, four-period crossover, glucose clamp study 23 nonsmoking subjects with type I diabetes received a dose of 0.19 units/kg inhaled human insulin followed in random order by either 1) no exercise (NOEX group) or 30 min exercise starting, 2) 30 min after dosing (EX30), 3) 120 min after dosing (EX120), or 4) 240 min after dosing (EX240). RESULTS - Exercise changed the shape of the free plasma insulin curves, but compared with the NOEX group the area under the curve for free plasma insulin (AUC(ins)) for the first 2 h after the start of exercise was unchanged for EX30 and EX240, while it was 15% decreased for EX120 (P < 0.01). The overall insulin absorption during 6 and 10 h after dosing was 13% decreased for EX30 (P < 0.005), 11% decreased for EX120 (P < 0.01), and unchanged for EX240. Exercise.), while the time to C-max was 22 min did not influence the maximum insulin concentration (C-max) earlier for EX30 (P = 0.04). The AUC for the glucose infusion rate (AUC(GIR)) for 2 h after the start of exercise increased by 58% for EX30, 45% for EX120, and 71% for EX240 (all P < 0.02) compared with the NOEX group. CONCLUSIONS - Thirty minutes of moderate exercise led to unchanged or decreased absorption of inhaled insulin via AERx iDMS and faster C-max for early exercise. Thus, patients using AERx iDMS can adjust insulin dose as usual independent of time of exercise, but they should be aware of the faster effect if exercising early after dosing.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Koehler, Gerd
(författare)
-
Korsatko, Stefan
(författare)
-
Wutte, Andrea
(författare)
-
Wonisch, Manfred
(författare)
-
Jeppesen, Ole K.
(författare)
-
Sparre, Thomas
(författare)
-
Clauson, Per
(författare)
-
Laursen, Torben
(författare)
-
Wollmer, PerLund University,Lunds universitet,Klinisk fysiologi och nuklearmedicin, Malmö,Forskargrupper vid Lunds universitet,Clinical Physiology and Nuclear Medicine, Malmö,Lund University Research Groups(Swepub:lu)klin-pwo
(författare)
-
Pieber, Thomas R.
(författare)
-
Klinisk fysiologi och nuklearmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Diabetes Care: American Diabetes Association30:10, s. 2571-25761935-55480149-5992
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Petersen, Astrid ...
-
Koehler, Gerd
-
Korsatko, Stefan
-
Wutte, Andrea
-
Wonisch, Manfred
-
Jeppesen, Ole K.
-
visa fler...
-
Sparre, Thomas
-
Clauson, Per
-
Laursen, Torben
-
Wollmer, Per
-
Pieber, Thomas R ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Diabetes Care
- Av lärosätet
-
Lunds universitet