Sökning: onr:"swepub:oai:lup.lub.lu.se:1a160021-4075-4daa-992e-0fd35b63ce4d" > Prognostically impo...
Fältnamn | Indikatorer | Metadata |
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000 | 05827naa a2200697 4500 | |
001 | oai:lup.lub.lu.se:1a160021-4075-4daa-992e-0fd35b63ce4d | |
003 | SwePub | |
008 | 160401s2002 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/1093982 URI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Mertens, Fredriku Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fme |
245 | 1 0 | a Prognostically important chromosomal aberrations in soft tissue sarcomas: a report of the Chromosomes and Morphology (CHAMP) Study Group. |
264 | 1 | c 2002 |
520 | a Cytogenetic analysis has not only provided important information on the pathogenesis of soft tissue tumors but, by disclosing distinct chromosomal rearrangements in different histopathological entities, has also come to serve as a valuable diagnostic tool. Little is known as yet about the potential prognostic impact of cytogenetic features detected in these tumors. A total of 239 benign and 221 malignant soft tissue tumors with clonal chromosome aberrations were subdivided according to general karyotypic features, such as degree of complexity and ploidy level, and rearrangements of specific chromosomal regions. The cytogenetic variables were analyzed regarding clinical outcome, using time to metastasis as the end point. Selected variables were then compared with established clinicopathological predictors of metastasis development. When the entire material was considered, 167 of 268 investigated cytogenetic variables were associated with clinical outcome. Focusing on the subset of 151 patients with high-grade sarcoma, 17 variables were identified that, besides grade and size, were associated with increased risk of metastasis development. A final Cox regression analysis identified five independent cytogenetic predictors of adverse outcome; breakpoints in chromosome regions 1p1, 1q4, 14q1, and 17q2, and gain of regions 6p1/p2. An increasing effect on metastatic risk was seen with increasing involvement of the selected cytogenetic variables, even when different histopathological types were studied separately. We conclude that cytogenetic data provide independent prognostic information in soft tissue sarcomas. Furthermore, our results point to specific areas of the genome harboring genes that may influence the metastatic potential of sarcoma cells. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Soft Tissue Neoplasms : secondary | |
653 | a Prognosis | |
653 | a Sarcoma : genetics | |
653 | a Soft Tissue Neoplasms : pathology | |
653 | a Sarcoma : secondary | |
653 | a Soft Tissue Neoplasms : genetics | |
653 | a Adolescence | |
653 | a Sarcoma : pathology | |
653 | a Adult | |
653 | a Child | |
653 | a Preschool | |
653 | a Female | |
653 | a Chromosome Aberrations | |
653 | a Follow-Up Studies | |
653 | a Human | |
653 | a Infant | |
653 | a Middle Age | |
653 | a Newborn | |
653 | a Male | |
700 | 1 | a Strömberg, Ulfu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)ymed-ust |
700 | 1 | a Mandahl, Nilsu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-nma |
700 | 1 | a Cin, Paola Dal4 aut |
700 | 1 | a De Wever, Ivo4 aut |
700 | 1 | a Fletcher, Christopher D M4 aut |
700 | 1 | a Mitelman, Felixu Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-fmi |
700 | 1 | a Rosai, Juan4 aut |
700 | 1 | a Rydholm, Andersu Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)ort-ary |
700 | 1 | a Sciot, Raf4 aut |
700 | 1 | a Tallini, Giovanni4 aut |
700 | 1 | a Van Den Berghe, Herman4 aut |
700 | 1 | a Vanni, Roberta4 aut |
700 | 1 | a Willén, Helena4 aut |
710 | 2 | a Avdelningen för klinisk genetikb Institutionen för laboratoriemedicin4 org |
773 | 0 | t Cancer Researchg 62:14, s. 3980-3984q 62:14<3980-3984x 1538-7445 |
856 | 4 | u http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12124330&dopt=Abstractx freey FULLTEXT |
856 | 4 | u http://cancerres.aacrjournals.org/cgi/content/full/62/14/3980x freey FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/109398 |
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