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Perturbed Insulin-l...
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McBeth, John
(författare)
Perturbed Insulin-like Growth Factor-1 (IGF-1) and IGF Binding Protein-3 Are Not Associated with Chronic Widespread Pain in Men: Results from the European Male Ageing Study.
- Artikel/kapitelEngelska2009
Förlag, utgivningsår, omfång ...
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2009-10-15
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The Journal of Rheumatology,2009
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:1cbac3cf-0025-49b0-9d32-fb9fdac51d17
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https://lup.lub.lu.se/record/1500275URI
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https://doi.org/10.3899/jrheum.090113DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
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OBJECTIVE: To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. METHODS: The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. RESULTS: A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. CONCLUSION: Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tajar, Abdelouahid
(författare)
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O'Neill, Terence W
(författare)
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Macfarlane, Gary J
(författare)
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Pye, Stephen R
(författare)
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Bartfai, Gyorgy
(författare)
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Boonen, Steven
(författare)
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Bouillon, Roger
(författare)
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Casanueva, Felipe
(författare)
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Finn, Joseph D
(författare)
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Forti, Gianni
(författare)
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Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups(Swepub:lu)kir-agi
(författare)
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Han, Thang S
(författare)
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Huhtaniemi, Ilpo T
(författare)
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Kula, Krzysztof
(författare)
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Lean, Michael E J
(författare)
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Pendleton, Neil
(författare)
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Punab, Margus
(författare)
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Silman, Alan J
(författare)
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Vanderschueren, Dirk
(författare)
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Wu, Frederick C W
(författare)
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Reproduktionsmedicin, MalmöForskargrupper vid Lunds universitet
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Rheumatology: The Journal of Rheumatology36, s. 2523-25300315-162X1499-2752
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McBeth, John
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Tajar, Abdelouah ...
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O'Neill, Terence ...
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Macfarlane, Gary ...
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Pye, Stephen R
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Bartfai, Gyorgy
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Boonen, Steven
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Bouillon, Roger
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Casanueva, Felip ...
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Finn, Joseph D
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Forti, Gianni
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Giwercman, Aleks ...
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Han, Thang S
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Huhtaniemi, Ilpo ...
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Kula, Krzysztof
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Lean, Michael E ...
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Pendleton, Neil
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Punab, Margus
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Silman, Alan J
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Vanderschueren, ...
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Wu, Frederick C ...
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