Sökning: onr:"swepub:oai:lup.lub.lu.se:1dbf435a-e3e3-4c28-b172-45f41e25d7b9" >
Cardiac q-space tra...
Cardiac q-space trajectory imaging by motion-compensated tensor-valued diffusion encoding in human heart in vivo
-
- Teh, Irvin (författare)
- Leeds School of Medicine
-
- Shelley, David (författare)
- Leeds Teaching Hospitals NHS Trust,Leeds School of Medicine
-
Boyle, Jordan H. (författare)
-
visa fler...
-
- Zhou, Fenglei (författare)
- University College London
-
- Poenar, Ana Maria (författare)
- Leeds School of Medicine
-
- Sharrack, Noor (författare)
- Leeds School of Medicine
-
- Foster, Richard J. (författare)
- Leeds School of Medicine
-
- Yuldasheva, Nadira Y. (författare)
- Leeds School of Medicine
-
- Parker, Geoff J.M. (författare)
- University College London,Bioxydyn Ltd
-
- Dall'Armellina, Erica (författare)
- Leeds School of Medicine
-
- Plein, Sven (författare)
- Leeds School of Medicine
-
- Schneider, Jürgen E. (författare)
- Leeds School of Medicine
-
- Szczepankiewicz, Filip (författare)
- Lund University,Lunds universitet,Medicinsk strålningsfysik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,MR Physics,Forskargrupper vid Lunds universitet,Multidimensional microstructure imaging,Medical Radiation Physics, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
-
visa färre...
-
(creator_code:org_t)
- 2023-03-20
- 2023
- Engelska 16 s.
-
Ingår i: Magnetic Resonance in Medicine. - : Wiley. - 0740-3194 .- 1522-2594. ; 90:1, s. 150-165
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Purpose: Tensor-valued diffusion encoding can probe more specific features of tissue microstructure than what is available by conventional diffusion weighting. In this work, we investigate the technical feasibility of tensor-valued diffusion encoding at high b-values with q-space trajectory imaging (QTI) analysis, in the human heart in vivo. Methods: Ten healthy volunteers were scanned on a 3T scanner. We designed time-optimal gradient waveforms for tensor-valued diffusion encoding (linear and planar) with second-order motion compensation. Data were analyzed with QTI. Normal values and repeatability were investigated for the mean diffusivity (MD), fractional anisotropy (FA), microscopic FA (μFA), isotropic, anisotropic and total mean kurtosis (MKi, MKa, and MKt), and orientation coherence (Cc). A phantom, consisting of two fiber blocks at adjustable angles, was used to evaluate sensitivity of parameters to orientation dispersion and diffusion time. Results: QTI data in the left ventricular myocardium were MD = 1.62 ± 0.07 μm2/ms, FA = 0.31 ± 0.03, μFA = 0.43 ± 0.07, MKa = 0.20 ± 0.07, MKi = 0.13 ± 0.03, MKt = 0.33 ± 0.09, and Cc = 0.56 ± 0.22 (mean ± SD across subjects). Phantom experiments showed that FA depends on orientation dispersion, whereas μFA was insensitive to this effect. Conclusion: We demonstrated the first tensor-valued diffusion encoding and QTI analysis in the heart in vivo, along with first measurements of myocardial μFA, MKi, MKa, and Cc. The methodology is technically feasible and provides promising novel biomarkers for myocardial tissue characterization.
Ämnesord
- NATURVETENSKAP -- Fysik -- Annan fysik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Other Physics Topics (hsv//eng)
Nyckelord
- cardiac microstructure
- diffusion tensor imaging
- motion-compensated diffusion encoding
- q-space trajectory imaging
- tensor-valued diffusion encoding
- tissue characterization
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Teh, Irvin
-
Shelley, David
-
Boyle, Jordan H.
-
Zhou, Fenglei
-
Poenar, Ana Mari ...
-
Sharrack, Noor
-
visa fler...
-
Foster, Richard ...
-
Yuldasheva, Nadi ...
-
Parker, Geoff J. ...
-
Dall'Armellina, ...
-
Plein, Sven
-
Schneider, Jürge ...
-
Szczepankiewicz, ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Fysik
-
och Annan fysik
- Artiklar i publikationen
-
Magnetic Resonan ...
- Av lärosätet
-
Lunds universitet