Sökning: onr:"swepub:oai:lup.lub.lu.se:260d917a-8484-4125-8903-2a76b0e06ad2" > Highly Accurate Blo...
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000 | 08631naa a2200577 4500 | |
001 | oai:lup.lub.lu.se:260d917a-8484-4125-8903-2a76b0e06ad2 | |
003 | SwePub | |
008 | 240226| | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/260d917a-8484-4125-8903-2a76b0e06ad22 URI |
024 | 7 | a https://doi.org/10.1038/s41591-024-02869-z2 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Barthélemy, Nicolas Ru Washington University School of Medicine4 aut |
245 | 1 0 | a Highly Accurate Blood Test for Alzheimer's Disease Comparable or Superior to Clinical CSF Tests |
300 | a 42 s. | |
520 | a With the emergence of Alzheimer's disease (AD) disease-modifying therapies, identifying patients who could benefit from these treatments becomes critical. We evaluated whether a precise blood test could perform as well as established cerebrospinal fluid (CSF) tests in detecting amyloid-β (Aβ) plaques and tau tangles. Plasma %p-tau217 (ratio of phosporylated-tau217 to non-phosphorylated tau) was analyzed by mass spectrometry in the Swedish BioFINDER-2 cohort (n=1,422) and the US Knight ADRC cohort (n=337). Matched CSF samples were analyzed with clinically used and FDA-approved automated immunoassays for Aβ42/40 and p-tau181/Aβ42. The primary and secondary outcomes were detection of brain Aβ or tau pathology, respectively, using PET imaging as the reference standard. Main analyses were focused on individuals with cognitive impairment (mild cognitive impairment and mild dementia), which is the target population for available disease-modifying treatments. Plasma %p-tau217 was clinically equivalent to FDA-approved CSF tests in classifying Aβ PET status, with an area-under-the-curve (AUC) for both between 0.95-0.97. Plasma %p-tau217 was generally superior to CSF tests in classification of tau-PET with AUCs of 0.95-0.98. In cognitively impaired sub-cohorts (BioFINDER-2: n=720; Knight ADRC: n=50), plasma %p-tau217 had an accuracy, positive predictive value and negative predictive value of 89-90% for Aβ PET and 87-88% for tau-PET status, which was clinically equivalent to CSF tests, further improving to 95% using a two cut-off approach. Blood plasma %p-tau217 demonstrated performance clinically equivalent or superior to clinically used FDA-approved CSF tests in the detection of AD pathology. Use of high performance blood tests in clinical practice can improve access to accurate AD diagnosis and AD-specific treatments. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Alzheimer's disease | |
653 | a Diagnosis | |
653 | a Diagnostic markers | |
700 | 1 | a Salvadó, Gemmau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)ge5655sa |
700 | 1 | a Schindler, Suzanneu Washington University School of Medicine4 aut |
700 | 1 | a He, Yingxinu Washington University School of Medicine4 aut |
700 | 1 | a Janelidze, Shorenau Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas4 aut0 (Swepub:lu)nkir-sje |
700 | 1 | a Collij, Lyduine Eu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam Neuroscience,Amsterdam UMC - Vrije Universiteit Amsterdam4 aut0 (Swepub:lu)ly4120co |
700 | 1 | a Saef, Benjaminu Washington University School of Medicine4 aut |
700 | 1 | a Henson, Rachel Lu Washington University School of Medicine4 aut |
700 | 1 | a Chen, Charles Du Washington University School of Medicine4 aut |
700 | 1 | a Gordon, Brian Au Washington University School of Medicine4 aut |
700 | 1 | a Li, Yanu Washington University in St. Louis,CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute4 aut |
700 | 1 | a La Joie, Renaudu University of California System4 aut |
700 | 1 | a Benzinger, Tammie L Su Washington University School of Medicine4 aut |
700 | 1 | a Morris, John Cu Washington University School of Medicine4 aut |
700 | 1 | a Mattsson-Carlgren, Niklasu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,WCMM- Wallenberg center för molekylär medicinsk forskning,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,WCMM-Wallenberg Centre for Molecular Medicine,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-nmn |
700 | 1 | a Palmqvist, Sebastianu Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-spa |
700 | 1 | a Ossenkoppele, Riku Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Amsterdam UMC - Vrije Universiteit Amsterdam,Amsterdam Neuroscience4 aut0 (Swepub:lu)ri1513os |
700 | 1 | a Rabinovici, Gil Du University of California System4 aut |
700 | 1 | a Stomrud, Eriku Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)med-esr |
700 | 1 | a Bateman, Randall Ju Washington University School of Medicine4 aut |
700 | 1 | a Hansson, Oskaru Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Department of Clinical Sciences, Malmö,Faculty of Medicine,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn |
710 | 2 | a Washington University School of Medicineb Institutionen för kliniska vetenskaper, Malmö4 org |
773 | 0 | t Nature Medicinex 1546-170X |
856 | 4 | u http://dx.doi.org/10.1038/s41591-024-02869-zy FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/260d917a-8484-4125-8903-2a76b0e06ad2 |
856 | 4 8 | u https://doi.org/10.1038/s41591-024-02869-z |
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