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Results of the firs...
Results of the first nationwide cohort study of outcomes in dialysis and kidney transplant patients before and after vaccination for COVID-19
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- Wijkström, Julia (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Caldinelli, Aurora (författare)
- Karolinska Institutet,Karolinska Institute,University of Milano-Bicocca,Karolinska Inst, Sweden; Univ Milano Bicocca, Italy
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- Bruchfeld, Annette (författare)
- Karolinska Institutet,Linköpings universitet,Linköping University,Karolinska Institute,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Karolinska Inst, Sweden
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- Nowak, Alexandra (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Artborg, Angelica (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden
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- Stendahl, Maria (författare)
- Ryhov County Hospital, Jönköping,Ryhov Hosp, Sweden; Swedish Renal Register, Sweden
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- Segelmark, Mårten (författare)
- Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Autoimmunitet och njursjukdomar,Forskargrupper vid Lunds universitet,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Autoimmunity and kidney diseases,Lund University Research Groups,Skåne University Hospital,Swedish Renal Register, Sweden; Lund Univ, Sweden; Skane Univ Hosp, Sweden
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- Lindholm, Bengt (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden
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- Bellocco, Rino (författare)
- Karolinska Institute,University of Milano-Bicocca,Karolinska Inst, Sweden
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- Rydell, Helena (författare)
- Karolinska Institute,Karolinska University Hospital,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Swedish Renal Register, Sweden
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- Evans, Marie (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden; Swedish Renal Register, Sweden,Karolinska University Hospital
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(creator_code:org_t)
- OXFORD UNIV PRESS, 2023
- 2023
- Engelska 10 s.
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Ingår i: Nephrology Dialysis Transplantation. - : OXFORD UNIV PRESS. - 0931-0509 .- 1460-2385. ; 38:11, s. 2607-2616
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background. Patients on kidney replacement therapy (KRT) have been identified as a vulnerable group during the coronavirus disease 2019 (COVID-19) pandemic. This study reports the outcomes of COVID-19 in KRT patients in Sweden, a country where patients on KRT were prioritized early in the vaccination campaign. Methods. Patients on KRT between January 2019 and December 2021 in the Swedish Renal Registry were included. Data were linked to national healthcare registries. The primary outcome was monthly all-cause mortality over 3 years of follow-up. The secondary outcomes were monthly COVID-19-related deaths and hospitalizations. The results were compared with the general population using standardized mortality ratios. The difference in risk for COVID-19-related outcomes between dialysis and kidney transplant recipients (KTRs) was assessed in multivariable logistic regression models before and after vaccinations started. Results. On 1 January 2020, there were 4097 patients on dialysis (median age 70 years) and 5905 KTRs (median age 58 years). Between March 2020 and February 2021, mean all-cause mortality rates increased by 10% (from 720 to 804 deaths) and 22% (from 158 to 206 deaths) in dialysis and KTRs, respectively, compared with the same period in 2019. After vaccinations started, all-cause mortality rates during the third wave (April 2021) returned to pre-COVID-19 mortality rates among dialysis patients, while mortality rates remained increased among transplant recipients. Dialysis patients had a higher risk for COVID-19 hospitalizations and death before vaccinations started {adjusted odds ratio [aOR] 2.1 [95% confidence interval (CI) 1.7–2.5]} but a lower risk after vaccination [aOR 0.5 (95% CI 0.4–0.7)] compared with KTRs. Conclusions. The COVID-19 pandemic in Sweden resulted in increased mortality and hospitalization rates among KRT patients. After vaccinations started, a distinct reduction in hospitalization and mortality rates was observed among dialysis patients, but not in KTRs. Early and prioritized vaccinations of KRT patients in Sweden probably saved many lives.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- COVID-19
- hospitalization
- mortality
- observational study
- renal replacement therapy
- COVID-19; hospitalization; mortality; observational study; renal replacement therapy
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Wijkström, Julia
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Caldinelli, Auro ...
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Bruchfeld, Annet ...
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Nowak, Alexandra
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Artborg, Angelic ...
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Stendahl, Maria
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Segelmark, Mårte ...
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Lindholm, Bengt
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Bellocco, Rino
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Rydell, Helena
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Evans, Marie
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
- Artiklar i publikationen
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Nephrology Dialy ...
- Av lärosätet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet