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UVB radiation repre...
UVB radiation represses CYLD expression in melanocytes
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- Kuphal, Silke (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Schneider, Nadja (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Massoumi, Ramin (författare)
- Lund University,Lunds universitet,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,Molecular Tumor Pathology,Lund University Research Groups
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- Hellerbrand, Claus (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
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- Bosserhoff, Anja Katrin (författare)
- Friedrich-Alexander University Erlangen-Nürnberg
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(creator_code:org_t)
- 2017-10-03
- 2017
- Engelska 7 s.
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Ingår i: Oncology Letters. - : Spandidos Publications. - 1792-1074 .- 1792-1082. ; 14:6, s. 7262-7268
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.spandido...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- CYLD lysine 63 deubiquitinase (CYLD) was originally identified as a tumor suppressor that is mutated in familial cylindromatosis. Unlike in cylindromatosis, downregulation of the deubiquitinase CYLD in melanoma, a highly aggressive tumor, is not caused by mutations in the CYLD gene, but rather by a constitutive and high expression of the snail family transcriptional repressor 1 (SNAIL1). A reduced CYLD level leads to B-cell lymphoma-3/p50/p52-dependent nuclear factorκB activation, which in turn triggers the expression of genes such as cyclin D1 and N-cadherin. Elevated levels of cyclin D1 and N-cadherin promote melanoma proliferation and invasion. By analyzing the regulation of CYLD expression in melanocytes, the present study identified a signaling pathway that is regulated in response to ultraviolet B (UVB) radiation in melanocytes. UVB light leads to an extracellular signal-regulated kinase-mediated induction of SNAIL1 and subsequent downregulation of CYLD expression in normal human epithelial melanocytes. The UVB-mediated suppression of CYLD in melanocytes may have a key role in the reaction to UV stimuli, and may also potentially be involved in the early malignant transformation processes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- CYLD
- ERK
- Melanocytes
- SNAIL1
- UVB
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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