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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04071naa a2200517 4500 | |
| 001 | oai:lup.lub.lu.se:346ab11e-37de-4fb2-a9b0-c850c405d4f6 | |
| 003 | SwePub | |
| 008 | 160401s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/19860872 URI |
| 024 | 7 | a https://doi.org/10.1016/j.bone.2011.03.6822 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Keyak, J. H.4 aut |
| 245 | 1 0 | a Male-female differences in the association between incident hip fracture and proximal femoral strength: A finite element analysis study |
| 264 | 1 | b Elsevier BV,c 2011 |
| 520 | a Hip fracture risk is usually evaluated using dual energy X-ray absorptiometry (DXA) or quantitative computed tomography (QCT) which provide surrogate measures for proximal femoral strength. However, proximal femoral strength can best be estimated explicitly by combining QCT with finite element (FE) analysis. To evaluate this technique for predicting hip fracture in older men and women, we performed a nested age- and sex-matched case-control study in the Age Gene/Environment Susceptibility (AGES) Reykjavik cohort. Baseline (pre-fracture) QCT scans of 5500 subjects were obtained. During 4-7 years follow-up, 51 men and 77 women sustained hip fractures. Ninety-seven men and 152 women were randomly selected as age- and sex-matched controls. FE-strength of the left hip of each subject for stance (F-Stance) and posterolateral fall (F-Fall) loading, and total femur areal bone mineral density (aBMD) were computed from the QCT data. F-Stance and F-Fall in incident hip fracture subjects were 13%-25% less than in control subjects (p <= 0.006) after controlling for demographic parameters. The difference between FE strengths of fracture and control subjects was disproportionately greater ill men (stance, 22%; fall, 25%) than in women (stance, 13%; fall, 18%) (p <= 0.033), considering that Fstar,ce and FFall in fracture subjects were greater in men than in women ( p < 0.001). For men, F-Stance was associated with hip fracture after accounting for aBMD (p = 0.013). These data indicate that F-Stance provides information about fracture risk that is beyond that provided by aBMD (p = 0.013). These findings support further exploration of possible sex differences in the predictors of hip fracture and of sex-specific strategies for using FE analysis to manage osteoporosis. (C) 2011 Elsevier Inc. All rights reserved. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Ortopedi0 (SwePub)302112 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Orthopaedics0 (SwePub)302112 hsv//eng |
| 653 | a Hip fracture | |
| 653 | a Femur | |
| 653 | a Bone strength | |
| 653 | a Finite element analysis | |
| 653 | a Osteoporosis | |
| 653 | a Quantitative computed tomography | |
| 700 | 1 | a Sigurdsson, S.4 aut |
| 700 | 1 | a Karlsdottir, G.4 aut |
| 700 | 1 | a Oskarsdottir, D.4 aut |
| 700 | 1 | a Sigmarsdottir, A.4 aut |
| 700 | 1 | a Zhao, S.4 aut |
| 700 | 1 | a Kornak, J.4 aut |
| 700 | 1 | a Harris, T. B.4 aut |
| 700 | 1 | a Sigurdsson, G.4 aut |
| 700 | 1 | a Jonsson, Brynjolfuru Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups4 aut0 (Swepub:lu)med-byj |
| 700 | 1 | a Siggeirsdottir, K.4 aut |
| 700 | 1 | a Eiriksdottir, G.4 aut |
| 700 | 1 | a Gudnason, V.4 aut |
| 700 | 1 | a Lang, T. F.4 aut |
| 710 | 2 | a Ortopedi - klinisk och molekylär osteoporosforskningb Forskargrupper vid Lunds universitet4 org |
| 773 | 0 | t Boned : Elsevier BVg 48:6, s. 1239-1245q 48:6<1239-1245x 1873-2763x 8756-3282 |
| 856 | 4 | u http://dx.doi.org/10.1016/j.bone.2011.03.682y FULLTEXT |
| 856 | 4 | u https://europepmc.org/articles/pmc3095704?pdf=render |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1986087 |
| 856 | 4 8 | u https://doi.org/10.1016/j.bone.2011.03.682 |
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