Plasma neurofilament light protein is differentially associated with age in individuals with treatment-resistant schizophrenia and bipolar affective disorder compared to controls

Wannan, Cassandra M.J.Orygen - National Centre for Excellence in Youth Mental Health,University of Melbourne (författare)

Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.

Eratne, DhamidhuRoyal Melbourne Hospital,University of Melbourne (författare)
Santillo, Alexander F.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas(Swepub:lu)med-ast (författare)
Malpas, CharlesUniversity of Melbourne (författare)
Cilia, BrandonRoyal Melbourne Hospital (författare)
Dean, Olivia M.The Florey Institute of Neuroscience and Mental Health,Deakin University (författare)
Walker, AdamDeakin University (författare)
Berk, MichaelDeakin University (författare)
Bousman, ChadUniversity of Melbourne,University of Calgary (författare)
Everall, IanKing's College London (författare)
Velakoulis, DennisUniversity of Melbourne,Royal Melbourne Hospital (författare)
Pantelis, ChristosUniversity of Melbourne,Monash University (författare)
Orygen - National Centre for Excellence in Youth Mental HealthUniversity of Melbourne (creator_code:org_t)
MiND Study Group

Av författaren/redakt...: Wannan, Cassandr ...; Eratne, Dhamidhu; Santillo, Alexan ...; Malpas, Charles; Cilia, Brandon; Dean, Olivia M.; visa fler...; Walker, Adam; Berk, Michael; Bousman, Chad; Everall, Ian; Velakoulis, Denn ...; Pantelis, Christ ...; visa färre...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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