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Poor Reproducibilit...
Poor Reproducibility of Allergic Rhinitis SNP Associations
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- Nilsson, Daniel (författare)
- Karolinska Institutet,Biomedicin
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- Andiappan, Anand Kumar (författare)
- National University of Singapore
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- Halldén, Christer (författare)
- Biomedicin
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- Tim, Chew Fook (författare)
- National University of Singapore
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- Säll, Torbjörn (författare)
- Lund University,Lunds universitet,MEMEG,Biologiska institutionen,Naturvetenskapliga fakulteten,Department of Biology,Faculty of Science,Forskningsmiljön Biomedicin
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- Wang, De Yun (författare)
- National University of Singapore
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- Cardell, Lars-Olaf (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2013-01-30
- 2013
- Engelska.
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://journals.plo...
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https://researchport... (primary) (free)
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https://doi.org/10.1... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Replication of reported associations is crucial to the investigation of complex disease. More than 100 SNPs have previously been reported as associated with allergic rhinitis (AR), but few of these have been replicated successfully. To investigate the general reproducibility of reported AR-associations in candidate gene studies, one Swedish (352 AR-cases, 709 controls) and one Singapore Chinese population (948 AR-cases, 580 controls) were analyzed using 49 AR-associated SNPs. The overall pattern of P-values indicated that very few of the investigated SNPs were associated with AR. Given published odds ratios (ORs) most SNPs showed high power to detect an association, but no correlations were found between the ORs of the two study populations or with published ORs. None of the association signals were in common to the two genome-wide association studies published in AR, indicating that the associations represent false positives or have much lower effect-sizes than reported.
Ämnesord
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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