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Meru couples planar...
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Banerjee, Jennifer J.Francis Crick Institute
(författare)
Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division
- Artikel/kapitelEngelska2017
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Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:59f3da3f-9e51-4709-8cdd-12cf2c06440c
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https://lup.lub.lu.se/record/59f3da3f-9e51-4709-8cdd-12cf2c06440cURI
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https://doi.org/10.7554/eLife.25014DOI
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Språk:engelska
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Sammanfattning på:engelska
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Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Aerne, Birgit L.Francis Crick Institute
(författare)
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Holder, Maxine V.Francis Crick Institute
(författare)
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Hauri, SimonLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine Proteomics,Forskargrupper vid Lunds universitet,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups(Swepub:lu)med-sh1
(författare)
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Gstaiger, MatthiasETH Zürich
(författare)
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Tapon, NicolasFrancis Crick Institute
(författare)
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Francis Crick InstituteInfektionsmedicin
(creator_code:org_t)
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