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Sökning: onr:"swepub:oai:lup.lub.lu.se:5b8df4c4-bfed-4db9-b8e0-890c1797cca1" > DNA Methylation of ...

  • Guo, YichenHarvard T.H. Chan School of Public Health (författare)

DNA Methylation of LRRC3B : A Biomarker for Survival of Early-Stage Non-Small Cell Lung Cancer Patients

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2018

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:5b8df4c4-bfed-4db9-b8e0-890c1797cca1
  • https://lup.lub.lu.se/record/5b8df4c4-bfed-4db9-b8e0-890c1797cca1URI
  • https://doi.org/10.1158/1055-9965.EPI-18-0454DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Previous studies support a tumor-suppressor role for LRRC3B across various types of cancers. We aimed to investigate the association between DNA methylation of LRRC3B and overall survival (OS) for patients with early-stage non-small cell lung cancer (NSCLC).Methods: This study included 1,230 patients with early-stage NSCLC. DNA was extracted from lung tumor tissues and DNA methylation was measured using Illumina Infinium HumanMethylation450 BeadChips. The association between DNA methylation and OS was first tested using Cox regression on a discovery cohort and then validated in an independent cohort. Next, the association between DNA methylation and gene expression was investigated in two independent cohorts. Finally, the association between gene expression and OS was investigated in three independent groups of patients.Results: Three novel DNA methylation sites in LRRC3B were significantly associated with OS in two groups of patients. Patients with hypermethylation in the DNA methylation sites had significantly longer survival than the others in both the discovery cohort (HR, 0.62; P = 2.02 × 10-05) and validation cohort (HR, 0.55; P = 4.44 × 10-04). The three DNA methylation sites were significantly associated with LRRC3B expression, which was also associated with OS.Conclusions: Using clinical data from a large population, we illustrated the association between DNA methylation of LRRC3B and OS of early-stage NSCLC.Impact: We provide evidence of plausibility for building biomarkers on DNA methylation of LRRC3B for OS of early-stage NSCLC, thus filling a gap between previous in vitro studies and clinical applications. Cancer Epidemiol Biomarkers Prev; 27(12); 1-9. ©2018 AACR.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zhang, RuyangNanjing Medical University (författare)
  • Shen, SipengNanjing Medical University (författare)
  • Wei, YongyueNanjing Medical University (författare)
  • Salama, Sebastian MoranUniversity of Barcelona (författare)
  • Fleischer, ThomasOslo university hospital (författare)
  • Bjaanæs, Maria MoksnesOslo university hospital (författare)
  • Karlsson, AnnaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-akn (författare)
  • Planck, MariaLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-mpl (författare)
  • Su, LiHarvard T.H. Chan School of Public Health (författare)
  • Zhu, ZhaozhongHarvard T.H. Chan School of Public Health (författare)
  • Staaf, JohanLund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups(Swepub:lu)onk-jst (författare)
  • Helland, ÅslaugUniversity of Oslo (författare)
  • Esteller, ManelUniversity of Barcelona (författare)
  • Christiani, David CHarvard T.H. Chan School of Public Health (författare)
  • Harvard T.H. Chan School of Public HealthNanjing Medical University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology27:12, s. 1527-15351538-7755

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