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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 05706naa a2200973 4500 | |
| 001 | oai:lup.lub.lu.se:5c713eb8-fb23-43dd-9d98-ace261f1d4a0 | |
| 003 | SwePub | |
| 008 | 160401s2011 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:umu-49957 | |
| 024 | 7 | a https://lup.lub.lu.se/record/22079702 URI |
| 024 | 7 | a https://doi.org/10.1038/bjc.2011.3712 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-499572 URI |
| 040 | a (SwePub)lud (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Tsilidis, K. K.4 aut |
| 245 | 1 0 | a Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition |
| 264 | c 2011-09-13 | |
| 264 | 1 | a London :b Springer Science and Business Media LLC,c 2011 |
| 300 | a 7 s. | |
| 520 | a BACKGROUND: It is well established that parity and use of oral contraceptives reduce the risk of ovarian cancer, but the associations with other reproductive variables are less clear. METHODS: We examined the associations of oral contraceptive use and reproductive factors with ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 327 396 eligible women, 878 developed ovarian cancer over an average of 9 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models stratified by centre and age, and adjusted for smoking status, body mass index, unilateral ovariectomy, simple hysterectomy, menopausal hormone therapy, and mutually adjusted for age at menarche, age at menopause, number of full-term pregnancies and duration of oral contraceptive use. RESULTS: Women who used oral contraceptives for 10 or more years had a significant 45% (HR, 0.55; 95% CI, 0.41-0.75) lower risk compared with users of 1 year or less (P-trend, <0.01). Compared with nulliparous women, parous women had a 29% (HR, 0.71; 95% CI, 0.59-0.87) lower risk, with an 8% reduction in risk for each additional pregnancy. A high age at menopause was associated with a higher risk of ovarian cancer (>52 vs <= 45 years: HR, 1.46; 95% CI, 1.06-1.99; P-trend, 0.02). Age at menarche, age at first full-term pregnancy, incomplete pregnancies and breastfeeding were not associated with risk. CONCLUSION: This study shows a strong protective association of oral contraceptives and parity with ovarian cancer risk, a higher risk with a late age at menopause, and no association with other reproductive factors. British Journal of Cancer (2011) 105, 1436-1442. doi:10.1038/bjc.2011.371 www.bjcancer.com Published online 13 September 2011 (C) 2011 Cancer Research UK | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 653 | a reproductive history | |
| 653 | a oral contraceptive use | |
| 653 | a ovarian cancer | |
| 653 | a cohort | |
| 653 | a study | |
| 653 | a reproductive history | |
| 700 | 1 | a Allen, N. E.4 aut |
| 700 | 1 | a Key, T. J.4 aut |
| 700 | 1 | a Dossus, L.4 aut |
| 700 | 1 | a Lukanova, A.4 aut |
| 700 | 1 | a Bakken, K.4 aut |
| 700 | 1 | a Lund, E.4 aut |
| 700 | 1 | a Fournier, A.4 aut |
| 700 | 1 | a Overvad, K.4 aut |
| 700 | 1 | a Hansen, L.4 aut |
| 700 | 1 | a Tjonneland, A.4 aut |
| 700 | 1 | a Fedirko, V.4 aut |
| 700 | 1 | a Rinaldi, S.4 aut |
| 700 | 1 | a Romieu, I.4 aut |
| 700 | 1 | a Clavel-Chapelon, F.4 aut |
| 700 | 1 | a Engel, P.4 aut |
| 700 | 1 | a Kaaks, R.4 aut |
| 700 | 1 | a Schuetze, M.4 aut |
| 700 | 1 | a Steffen, A.4 aut |
| 700 | 1 | a Bamia, C.4 aut |
| 700 | 1 | a Trichopoulou, A.4 aut |
| 700 | 1 | a Zylis, D.4 aut |
| 700 | 1 | a Masala, G.4 aut |
| 700 | 1 | a Pala, V.4 aut |
| 700 | 1 | a Galasso, R.4 aut |
| 700 | 1 | a Tumino, R.4 aut |
| 700 | 1 | a Sacerdote, C.4 aut |
| 700 | 1 | a Bueno-de-Mesquita, H. B.4 aut |
| 700 | 1 | a van Duijnhoven, F. J. B.4 aut |
| 700 | 1 | a Braem, M. G. M.4 aut |
| 700 | 1 | a Onland-Moret, N. C.4 aut |
| 700 | 1 | a Gram, I. T.4 aut |
| 700 | 1 | a Rodriguez, L.4 aut |
| 700 | 1 | a Travier, N.4 aut |
| 700 | 1 | a Sanchez, M-J4 aut |
| 700 | 1 | a Huerta, J. M.4 aut |
| 700 | 1 | a Ardanaz, E.4 aut |
| 700 | 1 | a Larranaga, N.4 aut |
| 700 | 1 | a Jirström, Karinu Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pat-kji |
| 700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
| 700 | 1 | a Idahl, Annikau Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002 |
| 700 | 1 | a Ohlson, Ninau Umeå universitet,Patologi4 aut0 (Swepub:umu)niaohn95 |
| 700 | 1 | a Khaw, K-T4 aut |
| 700 | 1 | a Wareham, N.4 aut |
| 700 | 1 | a Mouw, T.4 aut |
| 700 | 1 | a Norat, T.4 aut |
| 700 | 1 | a Riboli, E.4 aut |
| 710 | 2 | a Tumörmikromiljöb Sektion I4 org |
| 773 | 0 | t British Journal of Cancerd London : Springer Science and Business Media LLCg 105:9, s. 1436-1442q 105:9<1436-1442x 1532-1827x 0007-0920 |
| 856 | 4 | u http://dx.doi.org/10.1038/bjc.2011.371x freey FULLTEXT |
| 856 | 4 | u https://www.nature.com/articles/bjc2011371.pdf |
| 856 | 4 8 | u https://lup.lub.lu.se/record/2207970 |
| 856 | 4 8 | u https://doi.org/10.1038/bjc.2011.371 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49957 |
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- Tsilidis, K. K.
- Allen, N. E.
- Key, T. J.
- Dossus, L.
- Lukanova, A.
- Bakken, K.
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- Lund, E.
- Fournier, A.
- Overvad, K.
- Hansen, L.
- Tjonneland, A.
- Fedirko, V.
- Rinaldi, S.
- Romieu, I.
- Clavel-Chapelon, ...
- Engel, P.
- Kaaks, R.
- Schuetze, M.
- Steffen, A.
- Bamia, C.
- Trichopoulou, A.
- Zylis, D.
- Masala, G.
- Pala, V.
- Galasso, R.
- Tumino, R.
- Sacerdote, C.
- Bueno-de-Mesquit ...
- van Duijnhoven, ...
- Braem, M. G. M.
- Onland-Moret, N. ...
- Gram, I. T.
- Rodriguez, L.
- Travier, N.
- Sanchez, M-J
- Huerta, J. M.
- Ardanaz, E.
- Larranaga, N.
- Jirström, Karin
- Manjer, Jonas
- Idahl, Annika
- Ohlson, Nina
- Khaw, K-T
- Wareham, N.
- Mouw, T.
- Norat, T.
- Riboli, E.
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