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Sökning: onr:"swepub:oai:lup.lub.lu.se:6a0d9e42-7ddf-4cb1-a716-249f7be5ee5a" > The estimated effec...

  • Gaml-Sørensen, AnneUniversity of California, Los Angeles,Aarhus University (författare)

The estimated effect of season and vitamin D in the first trimester on pubertal timing in girls and boys : A cohort study and an instrumental variable analysis

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • 2023
  • 13 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:6a0d9e42-7ddf-4cb1-a716-249f7be5ee5a
  • https://lup.lub.lu.se/record/6a0d9e42-7ddf-4cb1-a716-249f7be5ee5aURI
  • https://doi.org/10.1093/ije/dyad060DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • Background: Season of birth has been associated with age at menarche. Maternal vitamin D levels in pregnancy may explain this effect. We investigated whether the season of first trimester or maternal 25-hydroxyvitamin D3 [25(OH)D3] levels were associated with pubertal timing in children. Methods: We conducted a follow-up study of 15 819 children born in 2000-03 from the Puberty Cohort, nested in the Danish National Birth Cohort (DNBC). Mean differences in attaining numerous pubertal markers, including a combined estimate for the average age at attaining all pubertal markers, were estimated for low (November-April) relative to high (May-October) sunshine exposure season in the first trimester using multivariable interval-censored regression models. Moreover, we conducted a two-sample instrumental variable analysis using season as an instrument for maternal first-Trimester 25(OH)D3 plasma levels obtained from a non-overlapping subset (n = 827) in the DNBC. Results: For the combined estimate, girls and boys of mothers who had their first trimester during November-April had earlier pubertal timing than girls and boys of mothers whose first trimester occurred during May-October:-1.0 months (95% CI:-1.7 to-0.3) and-0.7 months (95% CI:-1.4 to-0.1), respectively. In the instrumental variable analysis, girls and boys also had earlier pubertal timing: respectively,-1.3 months (95% CI:-2.1 to-0.4) and-1.0 months (95% CI:-1.8 to-0.2) per SD (22 nmol/L) decrease in 25(OH)D3. Conclusions: Both first pregnancy trimester during November-April and lower 25(OH)D3 were associated with earlier pubertal timing in girls and boys.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Brix, NisAarhus University,Aarhus University Hospital (författare)
  • Ernst, AndreasAarhus University,Aarhus University Hospital (författare)
  • Lunddorf, Lea Lykke HarritsAarhus University (författare)
  • Lindh, ChristianLund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli (författare)
  • Toft, GunnarAarhus University Hospital (författare)
  • Henriksen, Tine BrinkAarhus University Hospital (författare)
  • Arah, Onyebuchi A.Aarhus University,University of California, Los Angeles (författare)
  • Ramlau-Hansen, Cecilia HøstUniversity of California, Los Angeles,Aarhus University (författare)
  • University of California, Los AngelesAarhus University (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:International Journal of Epidemiology52:5, s. 1328-13400300-5771

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