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Plasma ascorbic aci...
Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes : the TEDDY study
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- Mattila, Markus (författare)
- University of Tampere,Finnish National Institute for Health and Welfare
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- Erlund, Iris (författare)
- Finnish National Institute for Health and Welfare
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- Lee, Hye Seung (författare)
- University of South Florida
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- Niinistö, Sari (författare)
- Finnish National Institute for Health and Welfare
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- Uusitalo, Ulla (författare)
- University of South Florida
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- Andrén Aronsson, Carin (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Hummel, Sandra (författare)
- Klinikum rechts der Isar,Helmholtz Zentrum München
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- Parikh, Hemang (författare)
- University of South Florida
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- Rich, Stephen S. (författare)
- University of Virginia
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- Hagopian, William (författare)
- Pacific Northwest Research Institute
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- Toppari, Jorma (författare)
- Turku University Hospital,University of Turku
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Ziegler, Anette G. (författare)
- Helmholtz Zentrum München,Klinikum rechts der Isar
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- Rewers, Marian (författare)
- University of Colorado
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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- Norris, Jill M. (författare)
- University of Colorado
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- Virtanen, Suvi M. (författare)
- Finnish National Institute for Health and Welfare,University of Tampere,Tampere University Hospital
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(creator_code:org_t)
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- 2019-11-14
- 2020
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 63:2, s. 278-286
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: We studied the association of plasma ascorbic acid with the risk of developing islet autoimmunity and type 1 diabetes and examined whether SNPs in vitamin C transport genes modify these associations. Furthermore, we aimed to determine whether the SNPs themselves are associated with the risk of islet autoimmunity or type 1 diabetes. Methods: We used a risk set sampled nested case–control design within an ongoing international multicentre observational study: The Environmental Determinants of Diabetes in the Young (TEDDY). The TEDDY study followed children with increased genetic risk from birth to endpoints of islet autoantibodies (350 cases, 974 controls) and type 1 diabetes (102 cases, 282 controls) in six clinical centres. Control participants were matched for family history of type 1 diabetes, clinical centre and sex. Plasma ascorbic acid concentration was measured at ages 6 and 12 months and then annually up to age 6 years. SNPs in vitamin C transport genes were genotyped using the ImmunoChip custom microarray. Comparisons were adjusted for HLA genotypes and for background population stratification. Results: Childhood plasma ascorbic acid (mean ± SD 10.76 ± 3.54 mg/l in controls) was inversely associated with islet autoimmunity risk (adjusted OR 0.96 [95% CI 0.92, 0.99] per +1 mg/l), particularly islet autoimmunity, starting with insulin autoantibodies (OR 0.94 [95% CI 0.88, 0.99]), but not with type 1 diabetes risk (OR 0.93 [95% Cl 0.86, 1.02]). The SLC2A2 rs5400 SNP was associated with increased risk of type 1 diabetes (OR 1.77 [95% CI 1.12, 2.80]), independent of plasma ascorbic acid (OR 0.92 [95% CI 0.84, 1.00]). Conclusions/interpretation: Higher plasma ascorbic acid levels may protect against islet autoimmunity in children genetically at risk for type 1 diabetes. Further studies are warranted to confirm these findings. Data availability: The datasets generated and analysed during the current study will be made available in the NIDDK Central Repository at https://www.niddkrepository.org/studies/teddy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Autoimmunity
- Plasma ascorbic acid
- Single nucleotide polymorphism
- SNP
- Transporter genes
- Type 1 diabetes
- Vitamin C
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Mattila, Markus
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Erlund, Iris
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Lee, Hye Seung
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Niinistö, Sari
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Uusitalo, Ulla
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Andrén Aronsson, ...
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visa fler...
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Hummel, Sandra
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Parikh, Hemang
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Rich, Stephen S.
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Hagopian, Willia ...
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Toppari, Jorma
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Lernmark, Åke
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Ziegler, Anette ...
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Rewers, Marian
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Krischer, Jeffre ...
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Norris, Jill M.
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Virtanen, Suvi M ...
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Diabetologia
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Lunds universitet