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Accuracy of 1-Hour ...
Accuracy of 1-Hour Plasma Glucose During the Oral Glucose Tolerance Test in Diagnosis of Type 2 Diabetes in Adults : A Meta-analysis
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- Ahuja, Vasudha (författare)
- Institute for Molecular Medicine Finland (FIMM),University of Helsinki
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- Aronen, Pasi (författare)
- University of Helsinki,Helsinki University Central Hospital
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- Pramodkumar, T. A. (författare)
- Madras Diabetes Research Foundation
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- Looker, Helen (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
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- Chetrit, Angela (författare)
- Gertner Institute for Epidemiology and Health Policy Research
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- Bloigu, Aini H. (författare)
- University of Oulu
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- Juutilainen, Auni (författare)
- University of Eastern Finland
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- Bianchi, Cristina (författare)
- University Hospital of Pisa
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- La Sala, Lucia (författare)
- IRCCS Multimedica
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- Anjana, Ranjit Mohan (författare)
- Madras Diabetes Research Foundation
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- Pradeepa, Rajendra (författare)
- Madras Diabetes Research Foundation
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- Venkatesan, Ulagamadesan (författare)
- Madras Diabetes Research Foundation
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- Jebarani, Sarvanan (författare)
- Madras Diabetes Research Foundation
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- Baskar, Viswanathan (författare)
- Madras Diabetes Research Foundation
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- Fiorentino, Teresa Vanessa (författare)
- University Magna Graecia
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- Timpel, Patrick (författare)
- Dresden University of Technology
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- DeFronzo, Ralph A. (författare)
- University of Texas Health Science Centre
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- Ceriello, Antonio (författare)
- IRCCS Multimedica
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- Del Prato, Stefano (författare)
- University Hospital of Pisa
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- Abdul-Ghani, Muhammad (författare)
- University of Texas Health Science Centre
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- Keinänen-Kiukaanniemi, Sirkka (författare)
- University of Oulu
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- Dankner, Rachel (författare)
- Gertner Institute for Epidemiology and Health Policy Research,Tel-Aviv University
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- Bennett, Peter H. (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
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- Knowler, William C. (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
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- Schwarz, Peter (författare)
- Dresden University of Technology,University Clinic Carl Gustav Carus at the TU Dresden,German Center for Diabetes Research
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- Sesti, Giorgio (författare)
- Sapienza University of Rome
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- Oka, Rie (författare)
- Hokuriku Central Hospital
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- Mohan, Viswanathan (författare)
- Madras Diabetes Research Foundation
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- Groop, Leif (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Institute for Molecular Medicine Finland (FIMM),University of Helsinki
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- Tuomilehto, Jaakko (författare)
- King Abdulaziz University,University of Helsinki,Finnish National Institute for Health and Welfare
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- Ripatti, Samuli (författare)
- University of Helsinki,Institute for Molecular Medicine Finland (FIMM),Broad Institute
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- Bergman, Michael (författare)
- New York University
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- Tuomi, Tiinamaija (författare)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,University of Helsinki,Folkhälsan Research Center,Institute for Molecular Medicine Finland (FIMM),Helsinki University Central Hospital
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(creator_code:org_t)
- 2021-03-15
- 2021
- Engelska 8 s.
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Ingår i: Diabetes Care. - : American Diabetes Association. - 1935-5548 .- 0149-5992. ; 44:4, s. 1062-1069
- Relaterad länk:
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http://dx.doi.org/10...
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https://helda.helsin...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: One-hour plasma glucose (1-h PG) during the oral glucose tolerance test (OGTT) is an accurate predictor of type 2 diabetes. We performed a meta-analysis to determine the optimum cutoff of 1-h PG for detection of type 2 diabetes using 2-h PG as the gold standard. RESEARCH DESIGN AND METHODS: We included 15 studies with 35,551 participants from multiple ethnic groups (53.8% Caucasian) and 2,705 newly detected cases of diabetes based on 2-h PG during OGTT. We excluded cases identified only by elevated fasting plasma glucose and/or HbA1c. We determined the optimal 1-h PG threshold and its accuracy at this cutoff for detection of diabetes (2-h PG ≥11.1 mmol/L) using a mixed linear effects regression model with different weights to sensitivity/specificity (2/3, 1/2, and 1/3). RESULTS: Three cutoffs of 1-h PG, at 10.6 mmol/L, 11.6 mmol/L, and 12.5 mmol/L, had sensitivities of 0.95, 0.92, and 0.87 and specificities of 0.86, 0.91, and 0.94 at weights 2/3, 1/2, and 1/3, respectively. The cutoff of 11.6 mmol/L (95% CI 10.6, 12.6) had a sensitivity of 0.92 (0.87, 0.95), specificity of 0.91 (0.88, 0.93), area under the curve 0.939 (95% confidence region for sensitivity at a given specificity: 0.904, 0.946), and a positive predictive value of 45%. CONCLUSIONS: The 1-h PG of ≥11.6 mmol/L during OGTT has a good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator to identify high-risk individuals is suggested to decrease the proportion of false-positive cases. Studies including other ethnic groups and assessing complication risk are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Till lärosätets databas
- Av författaren/redakt...
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Ahuja, Vasudha
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Aronen, Pasi
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Pramodkumar, T. ...
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Looker, Helen
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Chetrit, Angela
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Bloigu, Aini H.
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visa fler...
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Juutilainen, Aun ...
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Bianchi, Cristin ...
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La Sala, Lucia
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Anjana, Ranjit M ...
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Pradeepa, Rajend ...
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Venkatesan, Ulag ...
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Jebarani, Sarvan ...
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Baskar, Viswanat ...
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Fiorentino, Tere ...
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Timpel, Patrick
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DeFronzo, Ralph ...
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Ceriello, Antoni ...
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Del Prato, Stefa ...
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Abdul-Ghani, Muh ...
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Keinänen-Kiukaan ...
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Dankner, Rachel
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Bennett, Peter H ...
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Knowler, William ...
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Schwarz, Peter
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Sesti, Giorgio
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Oka, Rie
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Mohan, Viswanath ...
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Groop, Leif
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Tuomilehto, Jaak ...
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Ripatti, Samuli
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Bergman, Michael
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Tuomi, Tiinamaij ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Diabetes Care
- Av lärosätet
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Lunds universitet