Sökning: onr:"swepub:oai:lup.lub.lu.se:8982242e-ae43-4094-ab88-14b2e74a0f31" >
ANCA-associated glo...
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Göçeroǧlu, ArdaLeiden University Medical Centre
(författare)
ANCA-associated glomerulonephritis : Risk factors for renal relapse
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
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2016-12-14
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Public Library of Science (PLoS),2016
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8982242e-ae43-4094-ab88-14b2e74a0f31
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https://lup.lub.lu.se/record/8982242e-ae43-4094-ab88-14b2e74a0f31URI
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https://doi.org/10.1371/journal.pone.0165402DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Relapse in ANCA-associated vasculitis (AAV) has been studied previously, but there are few studies on renal relapse in particular. Identifying patients at high risk of renal relapse may aid in optimizing clinical management. We investigated which clinical and histological parameters are risk factors for renal relapse in ANCA-associated glomerulonephritis (AAGN). Patients (n = 174) were newly diagnosed and had mild±moderate or severe renal involvement. Data were derived from two trials of the European Vasculitis Society: MEPEX and CYCAZAREM. The Cox regression model was used to identify parameters increasing the instantaneous risk (= rate) of renal relapse (useful for instant clinical decisions). For identifying predictors of renal relapse during follow-up, we used Fine & Gray's regression model. Competing events were end-stage renal failure and death. The cumulative incidence of renal relapse at 5 years was 9.5% (95% CI: 4.8±14.3%). In the Cox model, sclerotic class AAGN increased the instantaneous risk of renal relapse. In Fine & Gray's model, the absence of interstitial infiltrates at diagnosis was predictive for renal relapse. In this study we used two different models to identify possible relationships between clinical and histopathological parameters at time of diagnosis of AAV with the risk of experiencing renal relapse. Sclerotic class AAGN increased the instantaneous risk of renal relapse. This association is most likely due to the high proportion of sclerosed glomeruli reducing the compensatory capacity. The absence of interstitial infiltrates increased the risk of renal relapse which is a warning sign that patients with a relatively benign onset of disease may also be prone to renal relapse. Renal relapses occurring in patients with sclerotic class AAGN and renal relapses occurring in patients without interstitial infiltrates were mutually exclusive, which may indicate that they are essentially different.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Berden, Annelies E.Leiden University Medical Centre
(författare)
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Fiocco, MartaLeiden University
(författare)
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Flobmann, OliverRoyal Berkshire Hospital
(författare)
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Westman, Kerstin W.Lund University,Lunds universitet,Njurmedicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Nephrology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)njur-kwe
(författare)
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Ferrario, FrancoUniversity of Milano-Bicocca
(författare)
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Gaskin, GillHammersmith Hospital
(författare)
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Pusey, Charles D.Hammersmith Hospital
(författare)
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Hagen, E. ChristiaanMeander Medical Center
(författare)
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Noë, Laure HélèneParis Descartes University
(författare)
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Rasmussen, NielsDanish Serum Institute, Copenhagen
(författare)
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Waldherr, RüdigerHeidelberg University
(författare)
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Walsh, MichaelMcMaster University
(författare)
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Bruijn, Jan A.Leiden University Medical Centre
(författare)
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Jayne, David R WAddenbrooke's Hospital
(författare)
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Bajema, Ingeborg M.Leiden University Medical Centre
(författare)
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Leiden University Medical CentreLeiden University
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:PLoS ONE: Public Library of Science (PLoS)11:121932-6203
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Göçeroǧlu, Arda
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Berden, Annelies ...
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Fiocco, Marta
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Flobmann, Oliver
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Westman, Kerstin ...
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Ferrario, Franco
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Gaskin, Gill
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Pusey, Charles D ...
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Hagen, E. Christ ...
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Noë, Laure Hélèn ...
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Rasmussen, Niels
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Waldherr, Rüdige ...
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Walsh, Michael
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Bruijn, Jan A.
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Jayne, David R W
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Bajema, Ingeborg ...
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