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Colectomy incidence...
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Panés, JuliánCIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd)
(författare)
Colectomy incidence rates in five-year data from the observational postmarketing ulcerative colitis study of originator infliximab
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-02-12
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Oxford University Press (OUP),2021
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5 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:8aa7d6e1-c761-4996-92cc-7ef7befa1d37
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https://lup.lub.lu.se/record/8aa7d6e1-c761-4996-92cc-7ef7befa1d37URI
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https://doi.org/10.1093/ibd/izab026DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background: This analysis of the Observational Postmarketing Ulcerative Colitis Study examined incidence rates of colectomy in patients with ulcerative colitis who received originator infliximab (IFX) or conventional therapies (ConvRx) as per their treating physician. Methods: Cox proportional hazards models compared time to colectomy for both treatment groups. A secondary analysis examined colectomy incidence rates based on IFX exposure timing (defined by a 90-day window after the last IFX dose date). Results: Of 2239 patients with data, 1059 enrolled in IFX and 1180 enrolled in ConvRx (including 296 patients who switched to IFX). Patients in the IFX group had more severe disease at baseline vs the ConvRx group (percentage with baseline partial Mayo score 7-9: 46.0% vs 30.5%, respectively). During 5 years of follow-up, 271 patients (12.1% of enrolled patients) had colectomy. Enrollment in the IFX group was associated with a higher risk of colectomy (hazard ratio = 3.12; 95% confidence interval, 2.25-4.34; P < 0.001) compared with enrollment in the ConvRx group. A total of 174 colectomies occurred in the IFX group, but 97 of these colectomies occurred ≥90 days after the last IFX dose date. Conclusions: Colectomy was reported at a higher rate in the IFX group than in the ConvRx group, although patients in the IFX group had more severe disease at baseline and most of the colectomies occurred after patients had been off of IFX for ≥90 days.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Lindsay, James O.
(författare)
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Teich, NielsFriedrich Schiller University Jena
(författare)
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Lindgren, StefanLund University,Lunds universitet,Gastroenterologi,Forskargrupper vid Lunds universitet,Gastroenterology,Lund University Research Groups(Swepub:lu)medf-sli
(författare)
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Colombel, Jean FrédéricIcahn School of Medicine at Mount Sinai
(författare)
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Flynn, Heather AnnMerck Sharp And Dohme Corp., US
(författare)
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Huyck, SusanMerck Sharp And Dohme Corp., US
(författare)
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Yao, RujiMerck Sharp And Dohme Corp., US
(författare)
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Philip, GeorgeMerck Sharp And Dohme Corp., US
(författare)
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Reinisch, WalterMedical University of Vienna
(författare)
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CIBER Enfermedades Hepaticas y Digestivas (CIBER-ehd)Friedrich Schiller University Jena
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Inflammatory Bowel Diseases: Oxford University Press (OUP)27:12, s. 1963-19671078-09981536-4844
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Till lärosätets databas
- Av författaren/redakt...
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Panés, Julián
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Lindsay, James O ...
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Teich, Niels
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Lindgren, Stefan
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Colombel, Jean F ...
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Flynn, Heather A ...
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visa fler...
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Huyck, Susan
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Yao, Ruji
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Philip, George
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Reinisch, Walter
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
- Artiklar i publikationen
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Inflammatory Bow ...
- Av lärosätet
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Lunds universitet