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The androgen recept...
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Eendebak, Robert J A HUniversity of Manchester
(författare)
The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men
- Artikel/kapitelEngelska2016
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:9ed84d39-a171-4364-836e-cb92b67c02b7
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https://lup.lub.lu.se/record/9ed84d39-a171-4364-836e-cb92b67c02b7URI
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https://doi.org/10.1530/EJE-16-0447DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Huhtaniemi, Ilpo T.Imperial College London
(författare)
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Pye, Stephen R.University of Manchester
(författare)
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Ahern, TomasUniversity of Manchester
(författare)
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W O'Neill, TerenceUniversity of Manchester
(författare)
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Bartfai, GyörgyUniversity of Szeged
(författare)
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Casanueva, Felipe F.University of Santiago de Compostela
(författare)
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Maggi, MarioUniversity of Florence
(författare)
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Forti, GianniUniversity of Florence
(författare)
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Alston, Robert D.University of Manchester
(författare)
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Giwercman, AleksanderLund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital(Swepub:lu)kir-agi
(författare)
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Han, Thang S.University College London
(författare)
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Kula, KrzysztofMedical University of Lodz
(författare)
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Lean, Michael E JUniversity of Glasgow
(författare)
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Punab, MargusUniversity of Tartu
(författare)
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Pendleton, NeilUniversity of Manchester
(författare)
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Keevil, Brian G.University Hospital of South Manchester NHS Foundation Trust
(författare)
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Vanderschueren, DirkCatholic University of Leuven
(författare)
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Rutter, Martin K.Manchester University NHS Foundation Trust,University of Manchester
(författare)
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Tampubolon, GindoUniversity of Manchester
(författare)
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Goodacre, RoystonUniversity of Manchester
(författare)
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Wu, Frederick C WUniversity of Manchester
(författare)
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University of ManchesterImperial College London
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Journal of Endocrinology175:6, s. 583-5930804-4643
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Eendebak, Robert ...
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Huhtaniemi, Ilpo ...
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Pye, Stephen R.
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Ahern, Tomas
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W O'Neill, Teren ...
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Bartfai, György
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visa fler...
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Casanueva, Felip ...
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Maggi, Mario
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Forti, Gianni
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Alston, Robert D ...
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Giwercman, Aleks ...
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Han, Thang S.
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Kula, Krzysztof
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Lean, Michael E ...
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Punab, Margus
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Pendleton, Neil
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Keevil, Brian G.
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Vanderschueren, ...
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Rutter, Martin K ...
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Tampubolon, Gind ...
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Goodacre, Roysto ...
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Wu, Frederick C ...
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