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- Kendler, Kenneth S.Virginia Commonwealth University (författare)
The Typology of Alcohol Use Disorder : Latent Class Analyses of a Population-Based Swedish Sample
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
- Alcohol Research Documentation, Inc.2022
- 8 s.
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:a82cd530-273f-400d-b5b6-f41d097b1821
- https://lup.lub.lu.se/record/a82cd530-273f-400d-b5b6-f41d097b1821URI
- https://doi.org/10.15288/jsad.21-00409DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Objective: The purpose of this study was to clarify the clinical heterogeneity of alcohol use disorder (AUD) in a national Swedish sample of affected individuals using latent class analysis. Method: Using a Swedish population-based sample of AUD cases ascertained from medical, criminal, and pharmacy registries (n = 217,071), we applied latent class analysis to sex, externalizing and internalizing syndromes before first registration, and age at first registration. The re-sulting types were evaluated against 15 diverse validators and degree of resemblance in relative pairs concordant for AUD. Results: A three-class solution was preferred by fit indices. The three classes were as follows: type 1 (male preponderant, externalizing; 32%), type 2 (minimal prior psychopathology; 46%), and type 3 (mixed-sex internalizing; 23%). Repeated split-half analyses revealed the statistical stability of these solutions. Meaningful differences emerged between the classes on many validators. Type 1 had the greatest family disruption, lowest educational levels, most AUD registrations, highest rates of criminal registration, and highest genetic risk for externalizing disorders and AUD. Type 2 had the least social dysfunction. Type 3 had the highest educational attainment, genetic liability to internalizing disorders, and proportion of women. All types significantly aggregated in affected pairs of relatives. Conclu-sions: Meaningful and reproducible subtypes of AUD, consistent with prior typological results, can be obtained from national registry–based samples. Using a range of external validators and patterns of familial aggregation, our results suggest that our three-class solution captured a meaningful proportion of the clinical heterogeneity of AUD.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
- Ohlsson, HenrikLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research(Swepub:lu)med-heo (författare)
- Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Community-Based Healthcare Research and Education (CoHRE),Center for Primary Health Care Research,Icahn School of Medicine at Mount Sinai,Shimane University(Swepub:lu)med-jsu (författare)
- Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Shimane University,Icahn School of Medicine at Mount Sinai,Center for Primary Health Care Research,Center for Community-Based Healthcare Research and Education (CoHRE)(Swepub:lu)med-ksq (författare)
- Virginia Commonwealth UniversityAllmänmedicin och klinisk epidemiologi (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Journal of Studies on Alcohol and Drugs: Alcohol Research Documentation, Inc.83:5, s. 672-6791937-18881938-4114
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- Journal of Studies on Alcohol and Drugs (Sök värdpublikationen i LIBRIS)
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