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Increased CXCL8 exp...
Increased CXCL8 expression is negatively correlated with the overall survival of patients with ER-negative breast cancer
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- Fang, Qi (författare)
- Third Affiliated Hospital of Soochow University
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- Wang, Xufen (författare)
- Third Affiliated Hospital of Soochow University
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- Luo, Guanghua (författare)
- Third Affiliated Hospital of Soochow University
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- Yu, Miaomei (författare)
- Third Affiliated Hospital of Soochow University
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- Zhang, Xiaoying (författare)
- Third Affiliated Hospital of Soochow University
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- Xu, Ning (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine
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(creator_code:org_t)
- Anticancer Research USA Inc. 2017
- 2017
- Engelska 8 s.
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Ingår i: Anticancer research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 37:9, s. 4845-4852
- Relaterad länk:
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http://dx.doi.org/10...
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http://ar.iiarjourna...
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https://lup.lub.lu.s...
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https://doi.org/10.2...
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Abstract
Ämnesord
Stäng
- Background: C-X-C motif chemokine ligand 8 (CXCL8) is a multi-functional chemokine and has important roles during tumor formation and development. It was previously reported that increased CXCL8 protein levels occurred in certain patients. Materials and Methods: In the present study, we examined levels of CXCL8 mRNA in breast cancer tissues and analyzed its levels in correlation to patients' clinical data and 10-year overall survival (OS). Results: Our results clearly demonstrated that the level of CXCL8 mRNA was significantly higher in patients without estrogen receptor expression. The receiver operating characteristic curve indicated that the best cut-off value for CXCL8 expression was 3.095 for predicting patient's OS. Conclusion: The present study demonstrated that higher CXCL8 mRNA levels in breast cancer tissues together with estrogen receptor negativity was associated with significantly shorter OS, and could be applied as a negative risk factor for 10-year OS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Breast cancer
- CXCL8
- Estrogen receptor
- Overall survival
- Progesterone receptor
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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