Sökning: onr:"swepub:oai:lup.lub.lu.se:aba6058c-293f-42a0-ab2f-35d8f163e22a" > U0126 attenuates ce...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04637naa a2200385 4500 | |
001 | oai:lup.lub.lu.se:aba6058c-293f-42a0-ab2f-35d8f163e22a | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/49086972 URI |
024 | 7 | a https://doi.org/10.1038/jcbfm.2014.2172 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Ahnstedt, Hildau Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-hat |
245 | 1 0 | a U0126 attenuates cerebral vasoconstriction and improves long-term neurologic outcome after stroke in female rats. |
264 | c 2015-03-01 | |
264 | 1 | b SAGE Publications,c 2015 |
520 | a Sex differences are well known in cerebral ischemia and may impact the effect of stroke treatments. In male rats, the MEK1/2 inhibitor U0126 reduces ischemia-induced endothelin type B (ETB) receptor upregulation, infarct size and improves acute neurologic function after experimental stroke. However, responses to this treatment in females and long-term effects on outcome are not known. Initial experiments used in vitro organ culture of cerebral arteries, confirming ERK1/2 activation and increased ETB receptor-mediated vasoconstriction in female cerebral arteries. Transient middle cerebral artery occlusion (tMCAO, 120 minutes) was induced in female Wistar rats, with U0126 (30 mg/kg intraperitoneally) or vehicle administered at 0 and 24 hours of reperfusion, or with no treatment. Infarct volumes were determined and neurologic function was assessed by 6-point and 28-point neuroscores. ETB receptor-mediated contraction was studied with myograph and protein expression with immunohistochemistry. In vitro organ culture and tMCAO resulted in vascular ETB receptor upregulation and activation of ERK1/2 that was prevented by U0126. Although no effect on infarct size, U0126 improved the long-term neurologic function after experimental stroke in female rats. In conclusion, early prevention of the ERK1/2 activation and ETB receptor-mediated vasoconstriction in the cerebral vasculature after ischemic stroke in female rats improves the long-term neurologic outcome.Journal of Cerebral Blood Flow & Metabolism advance online publication, 10 December 2014; doi:10.1038/jcbfm.2014.217. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
700 | 1 | a Mostajeran, Maryamu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-mmj |
700 | 1 | a Blixt, Franku Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-fbl |
700 | 1 | a Warfvinge, Karinu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)oft-kwa |
700 | 1 | a Ansar, Saemau Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-sbe |
700 | 1 | a Krause, Diana N4 aut |
700 | 1 | a Edvinsson, Larsu Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-led |
710 | 2 | a Medicin, Lundb Sektion II4 org |
773 | 0 | t Journal of Cerebral Blood Flow and Metabolismd : SAGE Publicationsg 35:3, s. 454-460q 35:3<454-460x 1559-7016x 0271-678X |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/25492115?dopt=Abstracty FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1038/jcbfm.2014.217y FULLTEXT |
856 | 4 | u https://journals.sagepub.com/doi/pdf/10.1038/jcbfm.2014.217 |
856 | 4 8 | u https://lup.lub.lu.se/record/4908697 |
856 | 4 8 | u https://doi.org/10.1038/jcbfm.2014.217 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy