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Efficacy and Toxici...
Efficacy and Toxicity of Intrathecal Liposomal Cytarabine in First-line Therapy of Childhood Acute Lymphoblastic Leukemia
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- Levinsen, Mette (författare)
- Copenhagen University Hospital
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- Harila-Saari, Arja (författare)
- Karolinska Institutet,Karolinska Institute
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- Grell, Kathrine (författare)
- University of Copenhagen
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- Jonsson, Olafur Gisli (författare)
- University of Iceland
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- Taskinen, Mervi (författare)
- University of Helsinki
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- Abrahamsson, Jonas (författare)
- Queen Silvia Children’s Hospital
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- Vettenranta, Kim (författare)
- Helsinki University Central Hospital
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- Åsberg, Ann (författare)
- St. Olav’s University Hospital
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- Risteli, Juha (författare)
- University of Helsinki
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- Heldrup, Jesper (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Schmiegelow, Kjeld (författare)
- University of Copenhagen
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(creator_code:org_t)
- 2016
- 2016
- Engelska.
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Ingår i: Journal of Pediatric Hematology/Oncology. - 1077-4114 .- 1536-3678. ; 38:8, s. 602-609
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We investigated efficacy and toxicity of replacing conventional triple (cytarabine, methotrexate, and hydrocortisone) intrathecal therapy (TIT) with liposomal cytarabine during maintenance therapy among 40 acute lymphoblastic leukemia patients. Twenty-eight of 29 patients in the TIT arm received TIT and 9/11 in the liposomal cytarabine arm received liposomal cytarabine. Arachnoiditis occurred in all initial 5 patients given liposomal cytarabine and intrathecal prednisolone succinate. Subsequently liposomal cytarabine was given with systemic dexamethasone. Neurotoxicity occurred at 6/27 liposomal cytarabine administrations with concomitant dexamethasone (22%). More liposomal cytarabine-treated patients experienced neurotoxicity in relation to intrathecal therapy during at least 1 cycle compared with TIT-treated patients (6/9 [67%] vs. 3/28 [11%], P=0.002). Apart from intermittent lower extremity sensory pain in 1 liposomal cytarabine-treated patient, no permanent adverse neurological sequelae were observed. In intention-to-treat analysis, projected 5-year event-free survival (pEFS-5y) was borderline higher for patients in the liposomal cytarabine arm compared with the TIT arm (1.0 vs. 0.69, P=0.046). However, pEFS-5y and projected 5-year relapse-free survival did not differ signficantly between patients treated with liposomal cytarabine or TIT (1.0 vs. 0.73, P=0.10; 1.0 vs. 0.76, P=0.12). Larger prospective trials are needed to explore whether liposomal cytarabine should be used as first-line prevention of relapse.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Lymphoblastic Leukemia
- Childhood
- Intrathecal Liposomal Cytarabine
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Levinsen, Mette
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Harila-Saari, Ar ...
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Grell, Kathrine
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Jonsson, Olafur ...
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Taskinen, Mervi
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Abrahamsson, Jon ...
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visa fler...
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Vettenranta, Kim
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Åsberg, Ann
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Risteli, Juha
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Heldrup, Jesper
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Schmiegelow, Kje ...
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visa färre...
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Lunds universitet
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Karolinska Institutet