onr:"swepub:oai:lup.lub.lu.se:b065f81f-6cd4-4608-b75f-6612e9b82d2b"
Sökning: onr:"swepub:oai:lup.lub.lu.se:b065f81f-6cd4-4608-b75f-6612e9b82d2b" > Regulation of Blood...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Dahlbäck, BjörnLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups (författare)
Regulation of Blood Coagulation by the Protein C Anticoagulant Pathway. Novel Insights Into Structure-Function Relationships and Molecular Recognition.
- Artikel/kapitelEngelska2005
Förlag, utgivningsår, omfång ...
- 2005
Nummerbeteckningar
- LIBRIS-ID:oai:lup.lub.lu.se:b065f81f-6cd4-4608-b75f-6612e9b82d2b
- https://lup.lub.lu.se/record/138256URI
- https://doi.org/10.1161/01.ATV.0000168421.13467.82DOI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- The protein C system provides important control of blood coagulation by regulating the activities of factor VIIIa (FVIIIa) and factor Va(FVa), cofactors in the activation of factor X and prothrombin, respectively. The system comprises membrane-bound and circulating proteins that assemble into multi-molecular complexes on cell surfaces. Vitamin K-dependent protein C, the key component of the system, circulates in blood as zymogen to an anticoagulant serine protease. It is efficiently activated on the surface of endothelial cells by thrombin bound to the membrane protein thrombomodulin. The endothelial protein C receptor (EPCR) further stimulates the protein C activation. Activated protein C (APC) together with its cofactor protein S inhibits coagulation by degrading FVIIIa and FVa on the surface of negatively charged phospholipid membranes. Efficient FVIIIa degradation by APC requires not only protein S but also intact FV, which like thrombin is a Janus-faced protein with both procoagulant and anticoagulant potential. In addition to its anticoagulant properties, APC has antiinflammatory and antiapoptotic functions, which are exerted when APC binds to EPCR and proteolytic cleaves protease-activated receptor 1 (PAR-1). The protein C system is physiologically important, and genetic defects affecting the system are the most common risk factors of venous thrombosis. The proteins of the protein C system are composed of multiple domains and the 3-dimensional structures of several of the proteins are known. The molecular recognition of the protein C system is progressively being unraveled, giving us new insights into this fascinating and intricate molecular scenario at the atomic level.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
- thrombomodulin
- factor V
- protein C
- protein S
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Villoutreix, Bruno O (författare)
- Klinisk kemi, MalmöForskargrupper vid Lunds universitet (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Arteriosclerosis, Thrombosis and Vascular Biology25:7, s. 1311-13201524-4636
Internetlänk
Hitta via bibliotek
- Arteriosclerosis, Thrombosis and Vascular Biology (Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Dahlbäck, Björn
- Villoutreix, Bru ...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Kardiologi
- Artiklar i publikationen
- Arteriosclerosis ...
- Av lärosätet
- Lunds universitet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
