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Associations of bre...
Associations of breastfeeding with childhood autoimmunity, allergies, and overweight : The Environmental Determinants of Diabetes in the Young (TEDDY) study
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- Hummel, Sandra (författare)
- Technical University of Munich
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- Weiß, Andreas (författare)
- Technical University of Munich
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- Bonifacio, Ezio (författare)
- Dresden University of Technology
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- Agardh, Daniel (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix
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- Aronsson, Carin A (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Hagopian, William A (författare)
- Pacific Northwest Research Institute
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- Koletzko, Sibylle (författare)
- Ludwig-Maximilian University of Munich
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- Krischer, Jeffrey P (författare)
- University of South Florida
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Skåne University Hospital
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- Lynch, Kristian (författare)
- University of South Florida
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- Norris, Jill M (författare)
- University of Colorado
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- Rewers, Marian J (författare)
- University of Colorado
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- She, Jin-Xiong (författare)
- Medical College of Georgia
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- Toppari, Jorma (författare)
- Turku University Hospital
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- Uusitalo, Ulla (författare)
- University of South Florida
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- Vehik, Kendra (författare)
- University of South Florida
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- Virtanen, Suvi M (författare)
- Finnish National Institute for Health and Welfare
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- Beyerlein, Andreas (författare)
- Technical University of Munich
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- Ziegler, Anette-G (författare)
- Technical University of Munich
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(creator_code:org_t)
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- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: The American journal of clinical nutrition. - : Elsevier BV. - 1938-3207 .- 0002-9165. ; 114:1, s. 134-142
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Abstract
Ämnesord
Stäng
- BACKGROUND: Breastfeeding has beneficial effects on numerous health outcomes.OBJECTIVES: We investigated whether breastfeeding duration is associated with the development of early childhood autoimmunity, allergies, or obesity in a multinational prospective birth cohort.METHODS: Infants with genetic susceptibility for type 1 diabetes (n = 8676) were followed for the development of autoantibodies to islet autoantigens or transglutaminase, allergies, and for anthropometric measurements to a median age of 8.3 y (IQR: 2.8-10.2 y). Information on breastfeeding was collected at 3 mo of age and prospectively thereafter. A propensity score for longer breastfeeding was calculated from the variables that were likely to influence any or exclusive breastfeeding. The risks of developing autoimmunity or allergy were assessed using Cox proportional hazards models, and the risk of obesity at 5.5 y of age was assessed using logistic regression with adjustment by the propensity score.RESULTS: Breastfeeding duration was not associated with a lower risk of either islet or transglutaminase autoimmunity (any breastfeeding >6 mo, adjusted HR: 1.07; 95% CI: 0.96, 1.19; exclusive breastfeeding >3 mo, adjusted HR: 1.03; 95% CI: 0.92, 1.15). Exclusive breastfeeding >3 mo was associated with a decreased risk of seasonal allergic rhinitis (adjusted HR: 0.70; 95% CI: 0.53, 0.92; P < 0.01). Any breastfeeding >6 mo and exclusive breastfeeding >3 mo were associated with decreased risk of obesity (adjusted OR: 0.62; 95% CI: 0.47, 0.81; P < 0.001; and adjusted OR: 0.68; 95% CI: 0.47, 0.95; P < 0.05, respectively).CONCLUSIONS: Longer breastfeeding was not associated with a lower risk of childhood (islet or transglutaminase) autoimmunity in genetically at-risk children but was associated with decreased risk of seasonal allergic rhinitis and obesity at 5.5 y of age.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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Hummel, Sandra
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Weiß, Andreas
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Bonifacio, Ezio
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Agardh, Daniel
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Akolkar, Beena
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Aronsson, Carin ...
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visa fler...
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Hagopian, Willia ...
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Koletzko, Sibyll ...
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Krischer, Jeffre ...
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Lernmark, Åke
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Lynch, Kristian
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Norris, Jill M
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Rewers, Marian J
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She, Jin-Xiong
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Toppari, Jorma
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Uusitalo, Ulla
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Vehik, Kendra
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Virtanen, Suvi M
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Beyerlein, Andre ...
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Ziegler, Anette- ...
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Lunds universitet