Sökning: onr:"swepub:oai:lup.lub.lu.se:bafd527b-45e1-47c0-a249-ba540613416f" >
Helicobacter pylori...
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Huang, JiaqiKarolinska Institute
(författare)
Helicobacter pylori infection, chronic corpus atrophic gastritis and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort : A nested case-control study
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-02-23
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Wiley,2017
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9 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:bafd527b-45e1-47c0-a249-ba540613416f
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https://lup.lub.lu.se/record/bafd527b-45e1-47c0-a249-ba540613416fURI
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https://doi.org/10.1002/ijc.30590DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133732URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:135414701URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The association between H. pylori infection and pancreatic cancer risk remains controversial. We conducted a nested case-control study with 448 pancreatic cancer cases and their individually matched control subjects, based on the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, to determine whether there was an altered pancreatic cancer risk associated with H. pylori infection and chronic corpus atrophic gastritis. Conditional logistic regression models were applied to calculate odds ratios (ORs) and corresponding 95% confidence intervals (CIs), adjusted for matching factors and other potential confounders. Our results showed that pancreatic cancer risk was neither associated with H. pylori seropositivity (OR = 0.96; 95% CI: 0.70, 1.31) nor CagA seropositivity (OR = 1.07; 95% CI: 0.77, 1.48). We also did not find any excess risk among individuals seropositive for H. pylori but seronegative for CagA, compared with the group seronegative for both antibodies (OR = 0.94; 95% CI: 0.63, 1.38). However, we found that chronic corpus atrophic gastritis was non-significantly associated with an increased pancreatic cancer risk (OR = 1.35; 95% CI: 0.77, 2.37), and although based on small numbers, the excess risk was particularly marked among individuals seronegative for both H. pylori and CagA (OR = 5.66; 95% CI: 1.59, 20.19, p value for interaction < 0.01). Our findings provided evidence supporting the null association between H. pylori infection and pancreatic cancer risk in western European populations. However, the suggested association between chronic corpus atrophic gastritis and pancreatic cancer risk warrants independent verification in future studies, and, if confirmed, further studies on the underlying mechanisms.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Zagai, UlrikaKarolinska Institutet,Karolinska Institute
(författare)
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Hallmans, GöranUmeå universitet,Umeå University,Institutionen för kostvetenskap(Swepub:umu)goha0001
(författare)
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Nyrén, OlofKarolinska Institute
(författare)
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Engstrand, LarsKarolinska Institutet,Karolinska Institute
(författare)
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Stolzenberg-Solomon, RachaelNational Cancer Institute, USA
(författare)
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Duell, Eric JCatalan Institute of Oncology
(författare)
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Overvad, KimAarhus University
(författare)
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Katzke, Verena AGerman Cancer Research Centre,Bellvitge University Hospital-IDIBELL
(författare)
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Kaaks, RudolfGerman Cancer Research Centre
(författare)
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Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization
(författare)
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Park, Jin YoungInternational Agency for Research on Cancer, World Health Organization
(författare)
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Murillo, RaulInternational Agency for Research on Cancer, World Health Organization
(författare)
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Trichopoulou, AntoniaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
(författare)
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Lagiou, PagonaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens,Harvard University
(författare)
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Bamia, ChristinaNational and Kapodistrian University of Athens,Hellenic Health Foundation, Athens
(författare)
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Bradbury, Kathryn EUniversity of Oxford
(författare)
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Riboli, ElioImperial College London
(författare)
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Aune, DagfinnImperial College London
(författare)
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Tsilidis, Konstantinos K.University of Ioannina,Imperial College London
(författare)
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Capellá, GabrielCatalan Institute of Oncology
(författare)
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Agudo, AntonioBellvitge University Hospital-IDIBELL
(författare)
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Krogh, VittorioIstituto Nazionale dei Tumori
(författare)
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Palli, DomenicoCancer Research and Prevention Institute (ISPO)
(författare)
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Panico, SalvatoreUniversity of Naples Federico II
(författare)
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Weiderpass, ElisabeteKarolinska Institutet,Karolinska Institute,Folkhälsan Research Center,UiT The Arctic University of Norway, Tromsø,Cancer Registry of Norway, Institute of Population-Based Cancer Research
(författare)
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Tjønneland, AnneDanish Cancer Society
(författare)
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Olsen, AnjaDanish Cancer Society
(författare)
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Martínez, BegoñaAndalusian School Of Public Health (EASP)
(författare)
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Redondo-Sanchez, DanielCIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP),University of Granada
(författare)
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Chirlaque, Maria DoloresMurcia Regional Health Council,University of Murcia,CIBER Epidemiology and Public Health (CIBERESP)
(författare)
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HM Peeters, PetraUniversity Medical Center Utrecht
(författare)
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Regnér, SaraLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups(Swepub:lu)kir-sre
(författare)
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Lindkvist, BjörnSahlgrenska University Hospital(Swepub:lu)kir-bl0
(författare)
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Naccarati, AlessioHuman Genetics Foundation (HuGeF)
(författare)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)(Swepub:lu)extLU-05
(författare)
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Larrañaga, NereaCIBER Epidemiology and Public Health (CIBERESP)
(författare)
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Boutron-Ruault, Marie-ChristineInstitut Gustave Roussy,Centre for Research in Epidemiology and Population Health (CESP),University of Paris-Saclay
(författare)
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Rebours, VincianeParis Diderot University
(författare)
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Barré, AmélieUniversity of Paris-Saclay
(författare)
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Bueno-De-Mesquita, Bas H.National Institute for Public Health and the Environment (RIVM),University of Malaya,Imperial College London,University Medical Center Utrecht
(författare)
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Ye, WeiminKarolinska Institutet,Umeå University,Karolinska Institute
(författare)
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Karolinska InstitutetKarolinska Institute
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Cancer: Wiley140:8, s. 1727-17350020-71361097-0215
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Huang, Jiaqi
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Zagai, Ulrika
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Hallmans, Göran
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Nyrén, Olof
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Engstrand, Lars
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Stolzenberg-Solo ...
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visa fler...
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Duell, Eric J
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Overvad, Kim
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Katzke, Verena A
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Kaaks, Rudolf
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Jenab, Mazda
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Park, Jin Young
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Murillo, Raul
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Trichopoulou, An ...
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Lagiou, Pagona
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Bamia, Christina
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Bradbury, Kathry ...
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Riboli, Elio
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Aune, Dagfinn
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Tsilidis, Konsta ...
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Capellá, Gabriel
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Agudo, Antonio
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Krogh, Vittorio
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Palli, Domenico
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Panico, Salvator ...
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Weiderpass, Elis ...
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Tjønneland, Anne
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Olsen, Anja
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Martínez, Begoña
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Redondo-Sanchez, ...
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Chirlaque, Maria ...
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HM Peeters, Petr ...
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Regnér, Sara
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Lindkvist, Björn
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Naccarati, Aless ...
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Ardanaz, Eva
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Larrañaga, Nerea
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Boutron-Ruault, ...
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Rebours, Vincian ...
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Barré, Amélie
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Bueno-De-Mesquit ...
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Ye, Weimin
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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International Jo ...
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Lunds universitet
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Umeå universitet
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Karolinska Institutet