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Reversine inhibits ...
Reversine inhibits Colon Carcinoma Cell Migration by Targeting JNK1
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- Jemaà, Mohamed (författare)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,University of Tübingen
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- Abassi, Yasmin (författare)
- Lund University,Lunds universitet,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,Molecular Tumor Pathology,Lund University Research Groups
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- Kifagi, Chamseddine (författare)
- Technical University of Denmark
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- Fezai, Myriam (författare)
- University of Tübingen
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- Daams, Renée (författare)
- Lund University,Lunds universitet,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,Molecular Tumor Pathology,Lund University Research Groups
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- Lang, Florian (författare)
- University of Tübingen,Heinrich Heine University Düsseldorf
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- Massoumi, Ramin (författare)
- Lund University,Lunds universitet,Molekylär tumörpatologi,Forskargrupper vid Lunds universitet,Molecular Tumor Pathology,Lund University Research Groups
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(creator_code:org_t)
- 2018-08-07
- 2018
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Colorectal cancer is one of the most commonly diagnosed cancers and the third most common cause of cancer-related death. Metastasis is the leading reason for the resultant mortality of these patients. Accordingly, development and characterization of novel anti-cancer drugs limiting colorectal tumor cell dissemination and metastasis are needed. In this study, we found that the small molecule Reversine reduces the migration potential of human colon carcinoma cells in vitro. A coupled kinase assay with bio-informatics approach identified the c-Jun N-terminal kinase (JNK) cascade as the main pathway inhibited by Reversine. Knockdown experiments and pharmacological inhibition identified JNK1 but not JNK2, as a downstream effector target in cancer cell migration. Xenograft experiments confirm the effect of JNK inhibition in the metastatic potential of colon cancer cells. These results highlight the impact of individual JNK isoforms in cancer cell metastasis and propose Reversine as a novel anti-cancer molecule for treatment of colon cancer patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (ämneskategori)
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