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Mucosal T lymphocyt...
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice
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Schon, M P (författare)
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Arya, A (författare)
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Murphy, E A (författare)
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visa fler...
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Adams, C M (författare)
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Strauch, U G (författare)
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- Agace, William (författare)
- Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups
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Marsal, J (författare)
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Donohue, J P (författare)
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Her, H (författare)
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Beier, D R (författare)
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Olson, S (författare)
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Lefrancois, L (författare)
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Brenner, M B (författare)
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Grusby, M J (författare)
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Parker, C M (författare)
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visa färre...
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Journal of Immunology. - 1550-6606. ; 162:11, s. 6641-6649
- Relaterad länk:
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http://www.jimmunol....
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- The mucosal lymphocyte integrin alpha E(CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or function. We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice. In alpha E-/- mice, intestinal and vaginal IEL numbers were reduced, consistent with the known binding of alpha E beta 7 to E-cadherin expressed on epithelial cells. However, it was surprising that lamina propria T lymphocyte numbers were diminished, as E-cadherin is not expressed in the lamina propria. In contrast, peribronchial, intrapulmonary, Peyer's patch, and splenic T lymphocyte numbers were not reduced in alpha E-deficient mice. Thus, alpha E beta 7 was important for generating or maintaining the gut and vaginal T lymphocytes located diffusely within the epithelium or lamina propria but not for generating the gut-associated organized lymphoid tissues. Finally, the impact of alpha E deficiency upon intestinal IEL numbers was greater at 3-4 wk of life than in younger animals, and affected the TCR alpha beta+ CD8+ T cells more than the gamma delta T cells or the TCR alpha beta+ CD4+CD8- population. These findings suggest that alpha E beta 7 is involved in the expansion/recruitment of TCR alpha beta+ CD8+ IEL following microbial colonization. Integrin alpha E-deficient mice will provide an important tool for studying the role of alpha E beta 7 and of alpha E beta 7-expressing mucosal T lymphocytes in vivo.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Schon, M P
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Arya, A
-
Murphy, E A
-
Adams, C M
-
Strauch, U G
-
Agace, William
-
visa fler...
-
Marsal, J
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Donohue, J P
-
Her, H
-
Beier, D R
-
Olson, S
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Lefrancois, L
-
Brenner, M B
-
Grusby, M J
-
Parker, C M
-
visa färre...
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Lunds universitet