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Sökning: onr:"swepub:oai:lup.lub.lu.se:c425b721-e539-4e88-8475-dd9c4af51632" > Enhanced predictive...

  • Pareek, MananOdense University Hospital,Brigham and Women's Hospital / Harvard Medical School (författare)

Enhanced predictive capability of a 1-hour oral glucose tolerance test : A prospective population-based cohort study

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • 2017-11-14
  • American Diabetes Association,2018
  • 7 s.

Nummerbeteckningar

  • LIBRIS-ID:oai:lup.lub.lu.se:c425b721-e539-4e88-8475-dd9c4af51632
  • https://lup.lub.lu.se/record/c425b721-e539-4e88-8475-dd9c4af51632URI
  • https://doi.org/10.2337/dc17-1351DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype

Anmärkningar

  • OBJECTIVE To examine whether the 1-h blood glucose measurement would be a more suitable screening tool for assessing the risk of diabetes and its complications than the 2-h measurement. RESEARCH DESIGN AND METHODS We conducted a prospective population-based cohort study of 4,867men, randomly selected fromprespecified birth cohorts between 1921 and 1949,who underwent an oral glucose tolerance test with blood glucose measurements at 0, 1, and 2 h. Subjects were followed for up to 39 years, with registry-based recording of events. Discriminative abilities of elevated 1-h (≥8.6 mmol/L) versus 2-h (≥7.8 mmol/L) glucose for predicting incident type 2 diabetes, vascular complications, andmortality were compared using Kaplan-Meier analysis, Cox proportional hazards regression, and net reclassification improvement. RESULTS Median agewas 48 years (interquartile range [IQR] 48-49). During follow-up (median 33 years [IQR 24-37]), 636 (13%) developed type 2 diabetes. Elevated 1-h glucose was associatedwith incident diabetes (hazard ratio 3.40 [95% CI 2.90-3.98], P < 0.001) and provided better risk assessment than impaired glucose tolerance (Harrell concordance index 0.637 vs. 0.511, P < 0.001). Addition of a 1-hmeasurement in subjects stratified by fasting glucose provided greater net reclassification improvement than the addition of a 2-h measurement (0.214 vs. 0.016, respectively). Finally, the 1-h glucose was significantly associated with vascular complications and mortality. CONCLUSIONS The 1-h blood glucose level is a stronger predictor of future type 2 diabetes than the 2-h level and is associated with diabetes complications and mortality.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Bhatt, Deepak L.Brigham and Women's Hospital / Harvard Medical School (författare)
  • Nielsen, Mette L.Odense University Hospital (författare)
  • Jagannathan, RamNew York University (författare)
  • Eriksson, Karl FredrikLund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-ker (författare)
  • Nilsson, Peter M.Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-pni (författare)
  • Bergman, MichaelNew York University (författare)
  • Olsen, Michael H.Odense University Hospital (författare)
  • Odense University HospitalBrigham and Women's Hospital / Harvard Medical School (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes Care: American Diabetes Association41:1, s. 171-1770149-59921935-5548

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