Antibody kinetics and clinical course of COVID-19 a prospective observational study

Bläckberg, AnnaLund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Skåne University Hospital (författare)

Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG and IgA towards SARS-CoV-2 spike protein were studied over time in patients with COVID-19. Possible associations between antibody titers and outcome were analyzed. Results Forty patients with COVID-19, hospitalized at Skåne University hospital, Sweden, between April and June 2020 were included. IgG antibody responses were detected for all patients with the highest levels four weeks after COVID-19 diagnosis. Levels of IgA were generally higher at diagnosis and decreased towards baseline 4 weeks after confirmed COVID-19. Patients with severe COVID-19 had higher levels of antibodies directed against SARS-CoV- 2 spike protein compared with patients with mild disease. Conclusion IgG and IgA antibodies towards the spike protein follow different kinetics during COVID-19 and patients with severe disease develop higher antibody levels.

Fernström, NilsLund University (författare)
Sarbrant, EmmaLund University (författare)
Rasmussen, MagnusLund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medk-mra (författare)
Sunnerhagen, TorgnyLund University,Lunds universitet,Translationell infektionsmedicin,Forskargrupper vid Lunds universitet,Translational infection medicine,Lund University Research Groups,Region Skåne(Swepub:lu)med-tsh (författare)
Translationell infektionsmedicinForskargrupper vid Lunds universitet (creator_code:org_t)

Av författaren/redakt...: Bläckberg, Anna; Fernström, Nils; Sarbrant, Emma; Rasmussen, Magnu ...; Sunnerhagen, Tor ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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