Progression of retinopathy in insulin-treated type 2 diabetic patients.

Henricsson, MarianneLund University,Lunds universitet,Oftalmologi (Malmö),Forskargrupper vid Lunds universitet,Ophthalmology (Malmö),Lund University Research Groups (författare)

OBJECTIVE—To study the progression of retinopathy 3 years after initiation of insulin therapy. RESEARCH DESIGN AND METHODS—In a prospective, observational case-control study, 42 type 2 diabetic patients were examined at baseline and 1, 3, 6, 12, 24, and 36 months after change to insulin therapy. Retinopathy was graded based on fundus photographs using the Wisconsin scale; HbA1c and IGF-1 were measured. RESULTS—During the observation period of 3 years, 26 patients progressed in the retinopathy scale; 11 patients progressed at least three levels. After 3 years of insulin therapy, HbA1c and IGF-1 were significantly lower than at baseline. Progression of retinopathy greater than or equal to three levels was related to high IGF-1 levels. CONCLUSIONS—A relationship was found between high IGF-1 levels at 3 years and progression of retinopathy in type 2 diabetic patients.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Treatment Outcome
Non-U.S. Gov't
Support
Prospective Studies
Middle Age
Non-Insulin-Dependent: physiopathology
Diabetic Retinopathy: physiopathology
Disease Progression
Logistic Models
Insulin: administration & dosage
Hypoglycemic Agents: administration & dosage
Human
Follow-Up Studies
Male
Female
Non-Insulin-Dependent: drug therapy
Diabetes Mellitus
Non-Insulin-Dependent: complications
Aged
Case-Control Studies

Berntorp, KerstinLund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups(Swepub:lu)endo-kbe (författare)
Fernlund, PerLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-pfe (författare)
Sundkvist, GöranLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine(Swepub:lu)endo-gsu (författare)
Oftalmologi (Malmö)Forskargrupper vid Lunds universitet (creator_code:org_t)

Ingår i:Diabetes Care: American Diabetes Association25:2, s. 381-3851935-55480149-5992

Av författaren/redakt...: Henricsson, Mari ...; Berntorp, Kersti ...; Fernlund, Per; Sundkvist, Göran

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

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