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Incidence and Predi...
Incidence and Predictors of Heart Failure in Patients With Atrial Fibrillation
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- Krisai, Philipp (författare)
- University Hospital Basel,Centre Hospitalier Universitaire de Bordeaux
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- Johnson, Linda S.B. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital,Hamilton Health Sciences
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- Moschovitis, Giorgio (författare)
- Hamilton Health Sciences
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- Benz, Alexander (författare)
- Hamilton Health Sciences
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- Ramasundarahettige, Chinthanie (författare)
- Hamilton Health Sciences
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- McIntyre, William F. (författare)
- Hamilton Health Sciences
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- Wong, Jorge A. (författare)
- Hamilton Health Sciences
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- Conen, David (författare)
- Hamilton Health Sciences
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- Sticherling, Christian (författare)
- University Hospital Basel
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- Connolly, Stuart J. (författare)
- Hamilton Health Sciences
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- Healey, Jeff S. (författare)
- Hamilton Health Sciences
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(creator_code:org_t)
- Elsevier BV, 2021
- 2021
- Engelska.
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Ingår i: CJC Open. - : Elsevier BV. - 2589-790X. ; 3:12, s. 1482-1489
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.cjcopen.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Heart failure (HF) is a frequent cause of hospitalization and death in patients with atrial fibrillation (AF). Identifying AF patients at risk of HF hospitalization could help select individuals for intensive follow-up and treatment. Methods: We pooled data from 3 randomized trials (ACTIVE-A, RE-LY, AVERROES) of AF patients, for derivation and internal validation of a risk score for first HF hospitalization. Secondary endpoints were cardiovascular death and a composite of HF hospitalizations and cardiovascular death. Results: In 23,503 patients, the mean age was 71.3 years, and 62% were male. Over a mean follow-up of 2.0 years, 875 patients (3.7%) experienced their first HF hospitalization, and 1037 patients (4.4%) died from cardiovascular causes. Incidence rates per 100 patient-years were 1.85 for HF hospitalizations, 2.15 for cardiovascular death, and 3.71 for the composite. Independent predictors for HF hospitalizations included the following: increased age, weight, heart rate and serum creatinine level, lower height and systolic blood pressure, diabetes, vascular disease, valvular disease, heart rhythm, left ventricular hypertrophy, and intraventricular conduction delay. The C-statistic (95% confidence intervals by bootstrap simulations) was 0.717 (0.705-0.732). At 2 years of follow-up, the incidence rate of the primary outcome increased across risk-score quintiles: 0.49, 0.87, 1.29, 2.44, and 4.51 per 100 patient-years, respectively. Patients in the highest quintile had an absolute risk of 6.8% for the primary endpoint at 2 years. Conclusions: In a large AF population, new-onset HF was common. A combination of characteristics can identify high-risk patients for whom strategies to prevent HF should be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- Av författaren/redakt...
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Krisai, Philipp
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Johnson, Linda S ...
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Moschovitis, Gio ...
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Benz, Alexander
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Ramasundarahetti ...
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McIntyre, Willia ...
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visa fler...
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Wong, Jorge A.
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Conen, David
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Sticherling, Chr ...
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Connolly, Stuart ...
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Healey, Jeff S.
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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CJC Open
- Av lärosätet
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Lunds universitet