The ratio of total cholesterol to high density lipoprotein cholesterol and myocardial infarction in Women's health in the Lund area (WHILA) : a 17-year follow-up cohort study

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Calling, SusannaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Skåne University Hospital,Center for Primary Health Care Research (författare)

The ratio of total cholesterol to high density lipoprotein cholesterol and myocardial infarction in Women's health in the Lund area (WHILA) : a 17-year follow-up cohort study

Artikel/kapitelEngelska2019

Förlag, utgivningsår, omfång ...

2019-10-29
Springer Science and Business Media LLC,2019

Nummerbeteckningar

LIBRIS-ID:oai:lup.lub.lu.se:d3e5e1fa-67b0-41b5-8c98-3fbb54ceaa7f
https://lup.lub.lu.se/record/d3e5e1fa-67b0-41b5-8c98-3fbb54ceaa7fURI
https://doi.org/10.1186/s12872-019-1228-7DOI

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Språk:engelska
Sammanfattning på:engelska

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Anmärkningar

BACKGROUND: Identifying variables predictive of acute myocardial infarction (AMI) in women is important. The use of the ratio of total cholesterol-to-high density lipoprotein cholesterol (TC/HDL-C) is often overlooked. The aim was to study TC/HDL-C in relation to later AMI, in a large sample of women, adjusted for age, educational status, smoking, waist-hip ratio, blood pressure, and neighbourhood socioeconomic status. The hypothesis was that increasing TC/HDL-C is associated with an increased risk of later AMI.METHODS: From December 1995 to February 2000, 6147 women aged 50-59 years from the Womens' Health in Lund area (WHILA) study in southern Sweden underwent a physical examination, laboratory tests and filled in a questionnaire. The women were followed through national registers for incidence of AMI during a mean follow up of 17 years.RESULTS: An increasing TC/HDL-C showed a strong relationship with AMI, with the lowest hazard ratio (HR = 1) in women with a ratio of ≤3.5. The HR for AMI was 1.14 (95% CI: 0.73-1.78) for those with a ratio between 3.5 and 4.0; in those with a ratio between 4.0 and 5.0 the HR for AMI was 1.46 (95% CI: 1.00-2.13) and in those with a ratio > 5.0 the HR was 1.89 (95% CI 1.26-2.82), after adjusting for potential confounding factors.CONCLUSIONS: TC/HDL-C ratio is a powerful predictor of AMI in middle-aged women. The results indicate that this variable should be used in clinical practice and is important for early identification of individuals at risk of AMI.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
Biomarkers/blood
Cholesterol/blood
Cholesterol, HDL/blood
Dyslipidemias/blood
Follow-Up Studies
Humans
Middle Aged
Myocardial Infarction/blood
Predictive Value of Tests
Prognosis
Prospective Studies
Risk Assessment
Risk Factors
Sweden/epidemiology
Time Factors
Women's Health

Biuppslag (personer, institutioner, konferenser, titlar ...)

Johansson, Sven-ErikSkåne University Hospital,Center for Primary Health Care Research(Swepub:lu)med-skj (författare)
Wolff, MoaLund University,Lunds universitet,Allmänmedicin och samhällsmedicin,Forskargrupper vid Lunds universitet,Family Medicine and Community Medicine,Lund University Research Groups,Skåne University Hospital,Center for Primary Health Care Research(Swepub:lu)med-mow (författare)
Sundquist, JanLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Skåne University Hospital,Center for Primary Health Care Research(Swepub:lu)med-jsu (författare)
Sundquist, KristinaLund University,Lunds universitet,Allmänmedicin och klinisk epidemiologi,Forskargrupper vid Lunds universitet,Family Medicine and Clinical Epidemiology,Lund University Research Groups,Center for Primary Health Care Research,Skåne University Hospital(Swepub:lu)med-ksq (författare)
Allmänmedicin och klinisk epidemiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Sammanhörande titlar

Ingår i:BMC Cardiovascular Disorders: Springer Science and Business Media LLC19:11471-2261

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Av författaren/redakt...: Calling, Susanna; Johansson, Sven- ...; Wolff, Moa; Sundquist, Jan; Sundquist, Krist ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Hälsovetenskap; och Folkhälsovetensk ...

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

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