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No interaction betw...
No interaction between H2 blockers and isoniazid
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Paulsen, Otto (författare)
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- Höglund, P (författare)
- Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Artificiell intelligens och thoraxkirurgisk vetenskap (AICTS),Forskargrupper vid Lunds universitet,Kliniska studier vid kronisk njursjukdom (CKD),Proteasinhibitorforskning,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Artificial Intelligence in CardioThoracic Sciences (AICTS),Lund University Research Groups,Clinical studies in CKD,Protease Inhibitor Research
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Nilsson, L G (författare)
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visa fler...
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Gredeby, H (författare)
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visa färre...
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(creator_code:org_t)
- 1986
- 1986
- Engelska.
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Ingår i: European Journal of Respiratory Diseases. - 0106-4339. ; 68:4, s. 90-286
- Relaterad länk:
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https://lup.lub.lu.s...
Abstract
Ämnesord
Stäng
- Antacids and anticholinergic drugs may delay gastric emptying and cause reduced absorption of isoniazid, but the influence of reduced gastric acidity has not been determined. In the present investigation, the influence of cimetidine and ranitidine on uptake and elimination of isoniazid was determined in six male and seven female healthy volunteers. The group comprised five rapid and eight slow acetylators, similar to the proportions in the general population. H2 blockers did not delay or reduce uptake of isoniazid, which thus seemed to be pH independent. Neither the acetylation of isoniazid nor the oxidative metabolism of acetylated isoniazid appeared to be affected by cimetidine or ranitidine.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Absorption
- Acetylation
- Adult
- Chromatography, High Pressure Liquid
- Cimetidine
- Drug Interactions
- Female
- Half-Life
- Histamine H2 Antagonists
- Humans
- Isoniazid
- Kinetics
- Male
- Middle Aged
- Ranitidine
- Spectrophotometry
- Time Factors
- Comparative Study
- Journal Article
- Research Support, Non-U.S. Gov't
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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